Traits

Traits linked to STK11

serine/threonine kinase 11

The Human Phenotype Ontology links 64 traits to STK11, by body system: features seen in people with one of the gene's rare conditions.

STK11

Abnormality of the digestive system

Trait	How often it is seen
Abdominal pain	Always
Bloody diarrhea	Always
Hamartomatous polyposis	Always
Intussusception	Always
Multiple gastric polyps	Always
Abnormality of the gastrointestinal tract	Very often (80–99%)
Gastrointestinal carcinoma	Very often (80–99%)
Abnormality of the gallbladder	Sometimes (5–29%)
Biliary tract neoplasm	Sometimes (5–29%)
Colon tumor	Sometimes (5–29%)
Death of digestive organ tissue due to poor blood supply	Sometimes (5–29%)
Esophageal tumor	Sometimes (5–29%)
Intestinal obstruction	Sometimes (5–29%)
Pancreatic adenocarcinoma	Sometimes (5–29%)
Rectal tumor	Sometimes (5–29%)
Rectum protrudes through anus	Sometimes (5–29%)
Small intestine tumor	Sometimes (5–29%)
Stomach cancer	Sometimes (5–29%)
Vomiting	Sometimes (5–29%)
Bile duct polyp	Not recorded
Biliary tract abnormality	Not recorded
Cancer of the pancreas	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormality of the ureter	Sometimes (5–29%)
Cancer starting in small tubes in kidneys	Sometimes (5–29%)
Cervix cancer	Sometimes (5–29%)
Enlarged ovaries with cysts	Sometimes (5–29%)
Multiple kidney cysts	Sometimes (5–29%)
Absent sperm in semen	Not recorded
Bladder polyp	Not recorded
Ovarian cyst	Not recorded
Teratoma	Not recorded
Uterine cancer	Not recorded

Abnormality of the integument

Trait	How often it is seen
Hyperpigmented skin patches	Always
Flat, discolored area of skin	Very often (80–99%)
Liver spots	Very often (80–99%)
Melanonychia	Sometimes (5–29%)
Atypical mole	Not recorded
Atypical nevi in non-sun exposed areas	Not recorded
Cutaneous melanoma	Not recorded
Numerous moles	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Labial melanotic macule	Always
Oral melanotic macule	Always
Abnormal color of the oral mucosa	Very often (80–99%)
Abnormality of the nose	Sometimes (5–29%)
Nasal polyposis	Sometimes (5–29%)
Nasal tumor	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Intestinal bleeding	Always
Gastrointestinal bleeding	Often (30–79%)
Low number of red blood cells or hemoglobin	Sometimes (5–29%)
Iron deficiency anemia	Not recorded

Abnormal tissue mass

Trait	How often it is seen
Abnormal tissue mass	Sometimes (5–29%)
Embryonal neoplasm	Not recorded

Abnormality of limbs

Trait	How often it is seen
Clubbing of fingers	Not recorded
Clubbing of fingers and toes	Not recorded

Abnormality of the breast

Trait	How often it is seen
Breast cancer	Sometimes (5–29%)
Enlarged male breast	Not recorded

Abnormality of the eye

Trait	How often it is seen
Abnormality of the eye	Not recorded
Uveal melanoma	Not recorded

Abnormality of the respiratory system

Trait	How often it is seen
Abnormality of the respiratory system	Sometimes (5–29%)
Lung cancer	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Elevated circulating alpha-fetoprotein concentration	Not recorded
Increased level of L-fucose in urine	Not recorded

Abnormality of prenatal development or birth

Trait	How often it is seen
Choriocarcinoma	Not recorded

Abnormality of the endocrine system

Trait	How often it is seen
Precocious puberty with Sertoli cell tumor	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to STK11 and how often each is seen. Find out more at hpo.jax.org.

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