Traits

Traits linked to NPR3

natriuretic peptide receptor 3

The Human Phenotype Ontology links 20 traits to NPR3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of limbs

Trait	How often it is seen
Pseudoepiphyses of the middle phalanges of the hand	Always
Pseudoepiphyses of the proximal phalanges of the hand	Always
Pseudoepiphysis of the 1st metacarpal	Always
Long big toe	Often (30–79%)
Long fingers	Often (30–79%)
Curvature of digit	Sometimes (5–29%)
Dropped arches	Sometimes (5–29%)
Long slender fingers	Sometimes (5–29%)
Long thumb	Sometimes (5–29%)
Long toe	Sometimes (5–29%)
Mallet finger	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Bulge in wall of root of large artery that carries blood away from heart	Often (30–79%)
Mitral valve prolapse	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Double-Jointed	Often (30–79%)
Funnel chest	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Zygomatic flattening	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Close sighted	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Abnormal gait	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Tall stature	Always

Laboratory abnormality

Trait	How often it is seen
Elevated alkaline phosphatase of bone origin	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NPR3 and how often each is seen. Find out more at hpo.jax.org.

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