Traits

Traits linked to LACC1

laccase domain multifunctional purine nucleosidase 1

The Human Phenotype Ontology links 27 traits to LACC1, by body system: features seen in people with one of the gene's rare conditions.

Laboratory abnormality

Trait	How often it is seen
Periodic fever	Always
Quotidian fever	Always
Elevated circulating C-reactive protein concentration	Very often (80–99%)
Fever	Very often (80–99%)
High ESR	Very often (80–99%)
Joint swelling	Very often (80–99%)
Elevated serum ferritin	Sometimes (5–29%)
Fluid around lungs	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Swollen lymph nodes	Often (30–79%)
increased pulmonary artery pressure	Sometimes (5–29%)
Increased spleen size	Sometimes (5–29%)
Swelling or irritation of membrane around heart	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Autoimmunity	Very often (80–99%)
Skin rash	Very often (80–99%)
Antinuclear antibody positivity	Often (30–79%)
Non-infectious meningitis	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Arthritis	Very often (80–99%)
Juvenile idiopathic arthritis	Very often (80–99%)
Osteopenia	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Elevated white blood count	Always
Increased number of platelets in blood	Always

Abnormality of the digestive system

Trait	How often it is seen
Abdominal pain	Sometimes (5–29%)
Enlarged liver	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Anterior uveitis	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Glomerulonephritis	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Joint pain	Very often (80–99%)

Growth abnormality

Trait	How often it is seen
Growth delay	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to LACC1 and how often each is seen. Find out more at hpo.jax.org.

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