Traits

Traits linked to IFRD1

interferon related developmental regulator 1

The Human Phenotype Ontology links 18 traits to IFRD1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Absent reflexes	Very often (80–99%)
Inability to coordinate movements when walking	Very often (80–99%)
Somatic sensory dysfunction	Very often (80–99%)
Difficulty articulating speech	Often (30–79%)
Lack of coordination of movement	Often (30–79%)
Nerve damage causing decreased feeling and movement	Often (30–79%)
Overactive lower leg reflex	Often (30–79%)
Twitching	Often (30–79%)
Degeneration of cerebellum	Sometimes (5–29%)
Head tremor	Sometimes (5–29%)
Peripheral axonal neuropathy	Sometimes (5–29%)
Titubation	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
High-arched foot	Often (30–79%)
Hyporeflexia of lower limbs	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Muscle weakness	Very often (80–99%)
Muscle degeneration	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Hearing impairment	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Involuntary, rapid, rhythmic eye movements	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to IFRD1 and how often each is seen. Find out more at hpo.jax.org.

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