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Gene

NYX

nyctalopin

Summary

Cytogenetic location
Xp11.4
Coordinates
Chromosome X: 41,447,343–41,475,652 (GRCh38)
Exons
3 exons across 28.3 kb
Protein
476 amino acids
Also known as
CLRP, CSNB1A
Previous symbols
CSNB1, CSNB4
MANE Select transcript
ENST00000378220.3NM_001378477.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Congenital Stationary Night Blindness

    • A group of mostly non-progressive retinal conditions, including Oguchi disease, caused by changes in genes such as NYX, CACNA1F, TRPM1, GRM6, GPR179 and SAG, often with nystagmus or short-sightedness.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      A genetic diagnosis explains the symptoms, helps distinguish the condition from progressive retinal diseases and informs family counselling.

How NYX is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome X, with a bracket where NYX sits. NYX and 5 genes near it on chromosome X, from 40,961,498 to 41,961,497.Chromosome XXp11.4p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q2841 Mb41.2 Mb41.4 Mb41.6 Mb41.8 MbUSP9X: 41,085,346–41,236,579, forward strandUSP9XDDX3X: 41,333,348–41,364,472, forward strandDDX3XNYX: 41,447,343–41,475,652, forward strandNYXCASK: 41,514,934–41,923,684, reverse strandCASKGPR34: 41,688,968–41,699,620, forward strandGPR34GPR82: 41,724,175–41,730,130, forward strandGPR82Diagram of NYX: 3 exons on the forward strand of chromosome XExon 3: 10 known disease-causing sitesExon 1: 41,447,343–41,447,516, 174 basesExon 2: 41,447,849–41,447,926, 78 basesExon 3: 41,473,491–41,475,652, 2,162 bases1235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 28.3 kb; 1,431 of those bases code for the protein.

How a genome test reads NYX

12

positions in NYX where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 28.3 kb of NYX, introns included, not only the 2.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NYX gene: nyctalopin. Retrieved 16 October 2026, from https://dantelabs.com/genes/nyx

Vancouver

Dante Labs. NYX gene: nyctalopin [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/nyx

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