Traits

Traits linked to FLT4

fms related receptor tyrosine kinase 4

The Human Phenotype Ontology links 47 traits to FLT4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the cardiovascular system

Trait	How often it is seen
Strawberry birthmark	Always
Underdeveloped lymphatic vessels	Always
Abnormal vein	Often (30–79%)
Tetralogy of Fallot	Often (30–79%)
Varicose veins	Often (30–79%)
Prominent veins	Sometimes (5–29%)
Absence of the pulmonary valve	Not recorded
Aortopulmonary collateral arteries	Not recorded
Double aortic arch	Not recorded
Narrowing of pulmonic valve	Not recorded
Pulmonary artery atresia	Not recorded
Right aortic arch	Not recorded
Strawberry mark	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Abnormal of nasal shape	Very often (80–99%)
Broad forehead	Very often (80–99%)
Decreased volume of lip	Often (30–79%)
Flattened bony protrusion above eyes	Often (30–79%)
Long, narrow head	Often (30–79%)
Pit in front of the ear	Often (30–79%)
Eye folds	Sometimes (5–29%)
Abnormal facial shape	Rarely (1–4%)

Abnormality of the integument

Trait	How often it is seen
Abnormal toenail development	Often (30–79%)
Hyperkeratosis	Often (30–79%)
Lichenification	Sometimes (5–29%)
Papilloma	Sometimes (5–29%)
Skin cancer	Sometimes (5–29%)
Upslanting toenail	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Curvature of little finger	Very often (80–99%)
Short fingers or toes	Very often (80–99%)
Ankle swelling	Often (30–79%)
Fluid accumulation in lower limbs	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Anxiety	Often (30–79%)
Depression	Often (30–79%)
Behavioral abnormality	Sometimes (5–29%)
Specific learning disability	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Predominantly lower limb lymphedema	Very often (80–99%)
Swelling caused by excess lymph fluid under skin	Very often (80–99%)
Nonimmune hydrops fetalis	Rarely (1–4%)
Hyperkeratosis over edematous areas	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Hydrocele testis	Often (30–79%)
Undescended testes	Often (30–79%)
Urethral stricture	Sometimes (5–29%)

Abnormal tissue mass

Trait	How often it is seen
Angiosarcoma	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Bulging eye	Often (30–79%)

Abnormality of the immune system

Trait	How often it is seen
Erysipelas	Rarely (1–4%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Bacterial infection of skin	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Prenatal growth deficiency	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to FLT4 and how often each is seen. Find out more at hpo.jax.org.

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