Traits

Traits linked to DNM1

dynamin 1

The Human Phenotype Ontology links 103 traits to DNM1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Absent speech development	Always
Choking episodes	Always
Clonus	Always
Epilepsy	Always
Epileptic encephalopathy	Always
Epileptic spasm	Always
Global developmental delay	Always
Hypsarrhythmia	Always
Increased reflexes	Always
Intellectual disability	Always
Myoclonic seizure	Always
Reduced cerebral white matter volume	Always
Severe global developmental delay	Always
Thin corpus callosum	Always
EEG with focal sharp slow waves	Very often (80–99%)
Encephalopathy	Very often (80–99%)
Inability to walk	Very often (80–99%)
Abnormal shape of brainstem	Often (30–79%)
Abnormality of coordination	Often (30–79%)
Agenesis of corpus callosum	Often (30–79%)
Aggressive behavior	Often (30–79%)
Atypical absence seizure	Often (30–79%)
Atypical absence status epilepticus	Often (30–79%)
Autism spectrum disorder	Often (30–79%)
Behavioral abnormality	Often (30–79%)
Brain degeneration	Often (30–79%)
Clonic seizure	Often (30–79%)
Colpocephaly	Often (30–79%)
Decreased reflex response	Often (30–79%)
Delayed speech and language development	Often (30–79%)
Diffuse cerebral atrophy	Often (30–79%)
EEG abnormality	Often (30–79%)
EEG with multifocal slow activity	Often (30–79%)
Falls	Often (30–79%)
Focal impaired awareness seizure	Often (30–79%)
Generalized tonic seizure	Often (30–79%)
Grand mal seizures	Often (30–79%)
Infantile spasms	Often (30–79%)
Involuntary movements	Often (30–79%)
Irritability	Often (30–79%)
Jerking	Often (30–79%)
Loss of developmental milestones	Often (30–79%)
Mental deterioration	Often (30–79%)
More active than typical	Often (30–79%)
Multifocal seizures	Often (30–79%)
Neurodevelopmental delay	Often (30–79%)
Personality disorder	Often (30–79%)
Self-injurious behavior	Often (30–79%)
Sudden loss of muscle tone	Often (30–79%)
Tonic seizure	Often (30–79%)
Ventriculomegaly	Often (30–79%)
Widened subarachnoid space	Often (30–79%)
Abnormal corpus callosum morphology	Sometimes (5–29%)
Abnormal gait	Sometimes (5–29%)
Abnormal myelination	Sometimes (5–29%)
Ataxia	Sometimes (5–29%)
Attention deficit	Sometimes (5–29%)
Autism	Sometimes (5–29%)
Degeneration of cerebrum	Sometimes (5–29%)
Diminished deep tendon reflex	Sometimes (5–29%)
Disorder of involuntary muscle movements	Sometimes (5–29%)
Generalized myoclonic seizure	Sometimes (5–29%)
Impulsivity	Sometimes (5–29%)
Lack of feeling, emotion, interest	Sometimes (5–29%)
Psychosis	Sometimes (5–29%)
Seizure affecting one half of brain	Sometimes (5–29%)
Tremor	Sometimes (5–29%)
Unsteady walk	Sometimes (5–29%)
Repeated seizures without recovery between them	Rarely (1–4%)

Abnormality of head or neck

Trait	How often it is seen
Almond shaped eyes	Always
Broad opening between the eyelids	Always
Development of small head that was not present at birth	Always
Narrow forehead	Always
Protruding tongue	Always
Broad face	Often (30–79%)
Gum enlargement	Often (30–79%)
Abnormally small head	Sometimes (5–29%)
Downward slanting of the opening between the eyelids	Sometimes (5–29%)
Failure of development of between one and six teeth	Sometimes (5–29%)
High forehead	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Appendicular spasticity	Always
Low muscle tone	Always
Poor head control	Always
Generalized decreased muscle tone	Often (30–79%)
Opisthotonus	Often (30–79%)
Involuntary muscle stiffness, contraction, or spasm	Sometimes (5–29%)
Rigidity	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Involuntary, rapid, rhythmic eye movements	Always
Optic atrophy	Often (30–79%)
Drooping upper eyelid	Sometimes (5–29%)
Abnormal involuntary eye movements	Rarely (1–4%)
Abnormality of vision	Rarely (1–4%)
Retina degeneration	Rarely (1–4%)

Abnormality of the digestive system

Trait	How often it is seen
Constipation	Always
Feeding difficulties	Often (30–79%)
Tube feeding	Often (30–79%)
Acid reflux	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Always
Dizziness	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Often (30–79%)
Short stature	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Increased muscle tone of arm or leg	Rarely (1–4%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Less than 10 fetal movements in 12 hours	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to DNM1 and how often each is seen. Find out more at hpo.jax.org.

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