Trait

Decreased circulating complement factor B concentration

Concentration of the complement component factor B in the blood circulation below the lower limit of normal.

Also called: Decreased serum complement factor B, Decreased serum factor b
Body system: Abnormality of the immune system

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page$trait$name

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5 genes linked to Decreased circulating complement factor B concentration

Changes in these genes cause rare conditions in which Decreased circulating complement factor B concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
CFIcomplement factor I	Often (30–79%)	In 1 condition
CFBcomplement factor B	Not recorded	In 1 condition
CFHcomplement factor H	Not recorded	In 1 condition
CFHR1complement factor H related 1	Not recorded	In 1 condition
CFHR3complement factor H related 3	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Reduced circulating complement concentration

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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