Traits

Traits linked to CDCA7

cell division cycle associated 7

The Human Phenotype Ontology links 36 traits to CDCA7, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Little lower jaw	Very often (80–99%)
Big calvaria	Often (30–79%)
Depressed nasal bridge	Often (30–79%)
Abnormally large tongue	Sometimes (5–29%)
Eye folds	Sometimes (5–29%)
Flat face	Sometimes (5–29%)
Protruding tongue	Sometimes (5–29%)
Abnormally small head	Not recorded
Short nose	Not recorded

Abnormality of the immune system

Trait	How often it is seen
Recurrent infections	Always
Decreased immune function	Very often (80–99%)
Recurrent respiratory infections	Very often (80–99%)
Cellular immunodeficiency	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Communicating hydrocephalus	Often (30–79%)
Global developmental delay	Often (30–79%)
Intellectual disability	Often (30–79%)
Motor delay	Often (30–79%)

Abnormal cellular phenotype

Trait	How often it is seen
Abnormality of chromosome stability	Very often (80–99%)
Decreased circulating antibody level	Very often (80–99%)
Agammaglobulinemia	Not recorded

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Abnormality of neutrophils	Often (30–79%)
Decreased blood lymphocyte number	Often (30–79%)
Low number of red blood cells or hemoglobin	Often (30–79%)

Abnormality of the ear

Trait	How often it is seen
Recurrent middle ear infection	Very often (80–99%)
Low-set ears	Sometimes (5–29%)
Conductive deafness	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Malabsorption	Often (30–79%)
Umbilical hernia	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Wide-set eyes	Sometimes (5–29%)
Cross-eyed	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Hypospadias	Not recorded
Undescended testes	Not recorded

Growth abnormality

Trait	How often it is seen
Short stature	Very often (80–99%)
Prenatal growth deficiency	Not recorded

Abnormality of limbs

Trait	How often it is seen
More than five fingers or toes on hands or feet	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Hypoplastic ischia	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CDCA7 and how often each is seen. Find out more at hpo.jax.org.

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