Traits

Traits linked to ANO10

anoctamin 10

The Human Phenotype Ontology links 37 traits to ANO10, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Brisk knee jerk	Always
Degeneration of cerebellum	Always
Difficulty articulating speech	Always
Hyperactive Achilles reflex	Always
Inability to coordinate movements when walking	Always
Limb ataxia	Always
Upper limb hyperreflexia	Always
Progressive cerebellar ataxia	Very often (80–99%)
Brisk reflexes	Often (30–79%)
Generalized-onset seizure	Often (30–79%)
Increased reflexes	Often (30–79%)
Instability or lack of coordination of central trunk muscles	Often (30–79%)
Lack of coordination of movement	Often (30–79%)
Muscle twitch	Often (30–79%)
Progressive gait ataxia	Often (30–79%)
Slurred speech	Often (30–79%)
Babinski sign	Sometimes (5–29%)
Intellectual disability	Sometimes (5–29%)
Intellectual disability, mild	Sometimes (5–29%)
Intention tremor	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Involuntary, rapid, rhythmic eye movements	Always
Downbeat nystagmus	Often (30–79%)
Drooping upper eyelid	Often (30–79%)
Hypermetric saccades	Often (30–79%)
Macular degeneration	Often (30–79%)
Saccadic smooth pursuit interruptions	Often (30–79%)
Uncoordinated eye movement	Often (30–79%)
Clouding of the lens of the eye	Sometimes (5–29%)
Double vision	Sometimes (5–29%)
Horizontal nystagmus	Sometimes (5–29%)
Slow eye movements	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Abnormal rhythmic movements of ankle	Often (30–79%)
High-arched foot	Often (30–79%)
Leg muscle stiffness	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Tortuosity of conjunctival vessels	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
EMG abnormality	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Abnormal circulating enzyme concentration or activity	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ANO10 and how often each is seen. Find out more at hpo.jax.org.

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