Traits

Traits linked to AGO1

argonaute RISC component 1

The Human Phenotype Ontology links 35 traits to AGO1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Delayed ability to walk	Always
Delayed speech and language development	Always
Febrile seizure (within the age range of 3 months to 6 years)	Always
Focal impaired awareness seizure	Always
Global developmental delay	Always
Globus pallidus calcification	Always
Grand mal seizures	Always
Intellectual disability	Always
IQ between 34 and 49	Always
More active than typical	Always
Repeated seizures without recovery between them	Always
Repetitive movements	Always
Anxiety	Very often (80–99%)
Autism spectrum disorder	Very often (80–99%)
Motor delay	Very often (80–99%)
Aggressive behavior	Often (30–79%)
Attention deficit	Often (30–79%)
Difficulty sleeping	Often (30–79%)
Epilepsy	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Bulbous nose	Always
Corners of eye widely separated	Always
Downward slanting of the opening between the eyelids	Always
Eye folds	Always
Round face	Always
Wide nasal bridge	Always
Almond shaped eyes	Not recorded
High forehead	Not recorded
Short nose	Not recorded
Thin red part of the upper lip	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties	Often (30–79%)
Acid reflux	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Large ears	Always

Abnormality of the eye

Trait	How often it is seen
Cross-eyed	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Mild short stature	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to AGO1 and how often each is seen. Find out more at hpo.jax.org.

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