Traits

Traits linked to ADGRV1

adhesion G protein-coupled receptor V1

The Human Phenotype Ontology links 50 traits to ADGRV1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Generalized-onset seizure	Very often (80–99%)
Brief seizures with staring spells	Often (30–79%)
Difficulty sleeping	Often (30–79%)
Febrile seizure (within the age range of 3 months to 6 years)	Often (30–79%)
Abnormality of balance	Sometimes (5–29%)
Anxiety	Sometimes (5–29%)
Ataxia	Sometimes (5–29%)
Atypical absence status epilepticus	Sometimes (5–29%)
Cognitive impairment	Sometimes (5–29%)
Cortical dysplasia	Sometimes (5–29%)
Depression	Sometimes (5–29%)
EEG with spike-wave complexes	Sometimes (5–29%)
Generalized cerebral degeneration/underdevelopment	Sometimes (5–29%)
Generalized myoclonic seizure	Sometimes (5–29%)
Grand mal seizures	Sometimes (5–29%)
Incoordination	Sometimes (5–29%)
Loss of developmental milestones	Sometimes (5–29%)
Poor fine motor coordination	Sometimes (5–29%)
Sudden loss of muscle tone	Sometimes (5–29%)
Autism spectrum disorder	Rarely (1–4%)
Focal impaired awareness seizure	Rarely (1–4%)
Obsessive-compulsive trait	Rarely (1–4%)
Repeated seizures without recovery between them	Rarely (1–4%)
Seizure affecting one half of brain	Rarely (1–4%)
Slow movements	Rarely (1–4%)
Tremor	Rarely (1–4%)
Generalized tonic seizure	Not recorded

Abnormality of the eye

Trait	How often it is seen
Abnormal electroretinogram	Very often (80–99%)
Blind spot	Very often (80–99%)
Light eye color	Very often (80–99%)
Rod-cone dystrophy	Very often (80–99%)
Visual loss	Very often (80–99%)
Close sighted	Often (30–79%)
Clouding of the lens of the eye	Often (30–79%)
Decreased clarity of vision	Often (30–79%)
Difficulties with night vision	Often (30–79%)
Limited peripheral vision	Often (30–79%)
Loss of peripheral vision	Often (30–79%)
Abnormal color vision	Sometimes (5–29%)
Reduced contrast sensitivity	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Dropped arches	Rarely (1–4%)
Limited knee straightening	Rarely (1–4%)
Talipes valgus	Rarely (1–4%)
Tibial torsion	Rarely (1–4%)

Abnormality of the ear

Trait	How often it is seen
Abnormality of the inner ear	Very often (80–99%)
Sensorineural hearing impairment	Very often (80–99%)
Abnormal vestibular function	Rarely (1–4%)
Congenital sensorineural hearing impairment	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ADGRV1 and how often each is seen. Find out more at hpo.jax.org.

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