{
  "url": "https://dantelabs.com/traits/reduced-left-ventricular-ejection-fraction",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "reduced-left-ventricular-ejection-fraction",
    "id": "HP:0012664",
    "name": "Reduced left ventricular ejection fraction",
    "definition": "A diminution of the volumetric fraction of blood pumped out of the ventricle with each cardiac cycle.",
    "synonyms": [
      "Reduced ejection fraction"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-left-ventricular-ejection-fraction",
        "name": "Abnormal left ventricular ejection fraction",
        "url": "https://dantelabs.com/traits/abnormal-left-ventricular-ejection-fraction"
      },
      {
        "slug": "left-ventricular-systolic-dysfunction",
        "name": "Left ventricular systolic dysfunction",
        "url": "https://dantelabs.com/traits/left-ventricular-systolic-dysfunction"
      }
    ],
    "narrower": [
      {
        "slug": "severely-reduced-left-ventricular-ejection-fraction",
        "name": "Severely reduced left ventricular ejection fraction",
        "genes": 23,
        "url": "https://dantelabs.com/traits/severely-reduced-left-ventricular-ejection-fraction"
      },
      {
        "slug": "mildly-reduced-left-ventricular-ejection-fraction",
        "name": "Mildly reduced left ventricular ejection fraction",
        "genes": 7,
        "url": "https://dantelabs.com/traits/mildly-reduced-left-ventricular-ejection-fraction"
      },
      {
        "slug": "moderately-reduced-left-ventricular-ejection-fraction",
        "name": "Moderately reduced left ventricular ejection fraction",
        "genes": 6,
        "url": "https://dantelabs.com/traits/moderately-reduced-left-ventricular-ejection-fraction"
      }
    ],
    "genes": [
      {
        "slug": "aars2",
        "symbol": "AARS2",
        "hgnc": "HGNC:21022",
        "name": "alanyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aars2"
      },
      {
        "slug": "abcc6",
        "symbol": "ABCC6",
        "hgnc": "HGNC:57",
        "name": "ATP binding cassette subfamily C member 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcc6"
      },
      {
        "slug": "coa6",
        "symbol": "COA6",
        "hgnc": "HGNC:18025",
        "name": "cytochrome c oxidase assembly factor 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coa6"
      },
      {
        "slug": "csrp3",
        "symbol": "CSRP3",
        "hgnc": "HGNC:2472",
        "name": "cysteine and glycine rich protein 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csrp3"
      },
      {
        "slug": "fktn",
        "symbol": "FKTN",
        "hgnc": "HGNC:3622",
        "name": "fukutin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fktn"
      },
      {
        "slug": "gatad1",
        "symbol": "GATAD1",
        "hgnc": "HGNC:29941",
        "name": "GATA zinc finger domain containing 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gatad1"
      },
      {
        "slug": "get3",
        "symbol": "GET3",
        "hgnc": "HGNC:752",
        "name": "guided entry of tail-anchored proteins factor 3, ATPase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/get3"
      },
      {
        "slug": "lama4",
        "symbol": "LAMA4",
        "hgnc": "HGNC:6484",
        "name": "laminin subunit alpha 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama4"
      },
      {
        "slug": "ldb3",
        "symbol": "LDB3",
        "hgnc": "HGNC:15710",
        "name": "LIM domain binding 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldb3"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "myh6",
        "symbol": "MYH6",
        "hgnc": "HGNC:7576",
        "name": "myosin heavy chain 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh6"
      },
      {
        "slug": "nexn",
        "symbol": "NEXN",
        "hgnc": "HGNC:29557",
        "name": "nexilin F-actin binding protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nexn"
      },
      {
        "slug": "raf1",
        "symbol": "RAF1",
        "hgnc": "HGNC:9829",
        "name": "Raf-1 proto-oncogene, serine/threonine kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/raf1"
      },
      {
        "slug": "rpl3l",
        "symbol": "RPL3L",
        "hgnc": "HGNC:10351",
        "name": "ribosomal protein L3 like",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl3l"
      },
      {
        "slug": "sdha",
        "symbol": "SDHA",
        "hgnc": "HGNC:10680",
        "name": "succinate dehydrogenase complex flavoprotein subunit A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdha"
      },
      {
        "slug": "sgcd",
        "symbol": "SGCD",
        "hgnc": "HGNC:10807",
        "name": "sarcoglycan delta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sgcd"
      },
      {
        "slug": "tnnt2",
        "symbol": "TNNT2",
        "hgnc": "HGNC:11949",
        "name": "troponin T2, cardiac type",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tnnt2"
      },
      {
        "slug": "vezf1",
        "symbol": "VEZF1",
        "hgnc": "HGNC:12949",
        "name": "vascular endothelial zinc finger 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vezf1"
      },
      {
        "slug": "myh7",
        "symbol": "MYH7",
        "hgnc": "HGNC:7577",
        "name": "myosin heavy chain 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh7"
      },
      {
        "slug": "rragd",
        "symbol": "RRAGD",
        "hgnc": "HGNC:19903",
        "name": "Ras related GTP binding D",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rragd"
      },
      {
        "slug": "scn5a",
        "symbol": "SCN5A",
        "hgnc": "HGNC:10593",
        "name": "sodium voltage-gated channel alpha subunit 5",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/scn5a"
      },
      {
        "slug": "acadvl",
        "symbol": "ACADVL",
        "hgnc": "HGNC:92",
        "name": "acyl-CoA dehydrogenase very long chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acadvl"
      },
      {
        "slug": "des",
        "symbol": "DES",
        "hgnc": "HGNC:2770",
        "name": "desmin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/des"
      },
      {
        "slug": "mybpc3",
        "symbol": "MYBPC3",
        "hgnc": "HGNC:7551",
        "name": "myosin binding protein C3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mybpc3"
      },
      {
        "slug": "nppa",
        "symbol": "NPPA",
        "hgnc": "HGNC:7939",
        "name": "natriuretic peptide A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nppa"
      },
      {
        "slug": "ttr",
        "symbol": "TTR",
        "hgnc": "HGNC:12405",
        "name": "transthyretin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttr"
      },
      {
        "slug": "vcl",
        "symbol": "VCL",
        "hgnc": "HGNC:12665",
        "name": "vinculin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vcl"
      },
      {
        "slug": "b2m",
        "symbol": "B2M",
        "hgnc": "HGNC:914",
        "name": "beta-2-microglobulin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b2m"
      },
      {
        "slug": "dysf",
        "symbol": "DYSF",
        "hgnc": "HGNC:3097",
        "name": "dysferlin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dysf"
      },
      {
        "slug": "fhod3",
        "symbol": "FHOD3",
        "hgnc": "HGNC:26178",
        "name": "formin homology 2 domain containing 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fhod3"
      },
      {
        "slug": "lama2",
        "symbol": "LAMA2",
        "hgnc": "HGNC:6482",
        "name": "laminin subunit alpha 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama2"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "polg2",
        "symbol": "POLG2",
        "hgnc": "HGNC:9180",
        "name": "DNA polymerase gamma 2, accessory subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg2"
      },
      {
        "slug": "psen2",
        "symbol": "PSEN2",
        "hgnc": "HGNC:9509",
        "name": "presenilin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen2"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "slc25a4",
        "symbol": "SLC25A4",
        "hgnc": "HGNC:10990",
        "name": "solute carrier family 25 member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a4"
      },
      {
        "slug": "twnk",
        "symbol": "TWNK",
        "hgnc": "HGNC:1160",
        "name": "twinkle mtDNA helicase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twnk"
      },
      {
        "slug": "ppcs",
        "symbol": "PPCS",
        "hgnc": "HGNC:25686",
        "name": "phosphopantothenoylcysteine synthetase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppcs"
      },
      {
        "slug": "ttn",
        "symbol": "TTN",
        "hgnc": "HGNC:12403",
        "name": "titin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttn"
      }
    ]
  }
}