Trait
Crumpled long bones
An crumpled radiographic appearance of the long bones, as if the long bone had been crushed together producing irregularities. This feature is the result of multiple fractures and repeated rounds of ineffective healing, as can be seen for instance in severe forms of osteogenesis imperfecta.
Summary
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Crumpled long bones, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test6 genes linked to Crumpled long bones
Changes in these genes cause rare conditions in which Crumpled long bones is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| COL1A1collagen type I alpha 1 chain | Always | In 1 condition |
| COL1A2collagen type I alpha 2 chain | Always | In 1 condition |
| CRTAPcartilage associated protein | Very often (80–99%) | In 2 conditions |
| P4HBprolyl 4-hydroxylase subunit beta | Very often (80–99%) | In 1 condition |
| SEC24DSEC24 homolog D, COPII component | Very often (80–99%) | In 1 condition |
| LRP5LDL receptor related protein 5 | Often (30–79%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks