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Gene

ZP1

zona pellucida glycoprotein 1

Summary

Cytogenetic location
11q12.2
Coordinates
Chromosome 11: 60,867,542–60,875,687 (GRCh38)
Exons
12 exons across 8.1 kb
Protein
638 amino acids
Also known as
ZPB1
MANE Select transcript
ENST00000278853.10NM_207341.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Female Infertility

    • inherited oocyte maturation defect
      • 2 GenCC submitters rate it definitive or strong

    • Diminished or absent ability of a female to achieve conception.

      • 2 GenCC submitters rate it definitive or strong

How ZP1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where ZP1 sits. ZP1 and 28 genes near it on chromosome 11, from 60,371,615 to 61,371,614.Chromosome 1111q12.2p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2560.4 Mb60.6 Mb60.8 Mb61 Mb61.2 MbMS4A6E: 60,327,251–60,396,596, forward strandMS4A6EMS4A7: 60,363,737–60,395,954, forward strandMS4A7MS4A14: 60,378,530–60,417,756, forward strandMS4A14MS4A5: 60,429,572–60,455,214, forward strandMS4A5MS4A1: 60,455,752–60,470,752, forward strandMS4A1MS4A12: 60,492,696–60,507,535, forward strandMS4A12MS4A13: 60,515,392–60,542,721, forward strandMS4A13MS4A8: 60,699,576–60,716,627, forward strandMS4A8MS4A18: 60,724,720–60,745,028, forward strandMS4A18MS4A15: 60,756,863–60,776,733, forward strandMS4A15MS4A10: 60,785,333–60,801,305, forward strandMS4A10CCDC86: 60,841,981–60,851,095, forward strandCCDC86PTGDR2: 60,850,933–60,855,987, reverse strandPTGDR2ZP1: 60,867,542–60,875,687, forward strandZP1PRPF19: 60,890,547–60,906,607, reverse strandPRPF19TMEM109: 60,912,521–60,923,443, forward strandTMEM109TMEM132A: 60,924,453–60,937,159, forward strandTMEM132ASLC15A3: 60,937,060–60,952,653, reverse strandSLC15A3CD6: 60,971,651–61,020,377, forward strandCD6CD5: 61,102,466–61,127,952, forward strandCD5VPS37C: 61,111,002–61,167,355, reverse strandVPS37CPGA3: 61,203,307–61,213,098, forward strandPGA3PGA4: 61,222,347–61,231,694, forward strandPGA4PGA5: 61,241,175–61,251,444, forward strandPGA5VWCE: 61,255,672–61,295,553, reverse strandVWCEDDB1: 61,299,447–61,342,596, reverse strandDDB1TKFC: 61,333,205–61,354,339, forward strandTKFCCYB561A3: 61,348,453–61,362,343, reverse strandCYB561A3TMEM138: 61,361,964–61,377,890, forward strandTMEM138Diagram of ZP1: 12 exons on the forward strand of chromosome 11Exon 2: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 7: 3 known disease-causing sitesExon 9: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 11: 2 known disease-causing sitesExon 1: 60,867,542–60,867,757, 216 basesExon 2: 60,869,145–60,869,266, 122 basesExon 3: 60,869,537–60,869,900, 364 basesExon 4: 60,870,332–60,870,475, 144 basesExon 5: 60,870,957–60,871,144, 188 basesExon 6: 60,871,217–60,871,314, 98 basesExon 7: 60,873,162–60,873,289, 128 basesExon 8: 60,873,375–60,873,564, 190 basesExon 9: 60,873,634–60,873,775, 142 basesExon 10: 60,874,933–60,875,014, 82 basesExon 11: 60,875,129–60,875,248, 120 basesExon 12: 60,875,514–60,875,687, 174 bases1234567891011125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2 kb of the gene's 8.1 kb; 1,917 of those bases code for the protein.

How a genome test reads ZP1

14

positions in ZP1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 8.1 kb of ZP1, introns included, not only the 2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ZP1 gene: zona pellucida glycoprotein 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/zp1

Vancouver

Dante Labs. ZP1 gene: zona pellucida glycoprotein 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/zp1

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