Traits

Traits linked to TET3

tet methylcytosine dioxygenase 3

The Human Phenotype Ontology links 38 traits to TET3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Delayed motor skills	Always
Delayed speech and language development	Always
Global developmental delay	Always
Poor social interactions	Always
Autism spectrum disorder	Very often (80–99%)
Delayed fine motor development	Very often (80–99%)
Intellectual disability	Very often (80–99%)
Anxiety	Often (30–79%)
Attention deficit	Often (30–79%)
EEG abnormality	Often (30–79%)
Epilepsy	Often (30–79%)
Depression	Sometimes (5–29%)
Extra-axial cerebrospinal fluid accumulation	Sometimes (5–29%)
Periventricular leukomalacia	Sometimes (5–29%)
Ventriculomegaly	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Broad head shape	Often (30–79%)
Decreased facial muscle tone	Often (30–79%)
High palate	Often (30–79%)
Long face	Often (30–79%)
Long philtrum	Often (30–79%)
Open mouth	Often (30–79%)
Abnormally small head	Sometimes (5–29%)
Big calvaria	Sometimes (5–29%)
Narrowing of the tear duct	Sometimes (5–29%)
Broad forehead	Not recorded
High forehead	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Generalized decreased muscle tone	Often (30–79%)
Abnormal formation of the hip	Sometimes (5–29%)
Advanced bone age	Sometimes (5–29%)
Double-Jointed	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Cross-eyed	Sometimes (5–29%)
Drooping upper eyelid	Sometimes (5–29%)
Involuntary, rapid, rhythmic eye movements	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Enlarged heart	Sometimes (5–29%)
Hole in heart wall separating two lower heart chambers	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Dropped arches	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties in infancy	Often (30–79%)

Abnormality of the ear

Trait	How often it is seen
Prominent ear	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TET3 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test