Traits

Traits linked to TAC3

tachykinin precursor 3

The Human Phenotype Ontology links 44 traits to TAC3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the genitourinary system

Trait	How often it is seen
Decreased testicular size	Always
Primary amenorrhea	Always
Short penis	Always
Absent sperm in semen	Very often (80–99%)
Difficulty getting a full erection	Very often (80–99%)
Increased female sex drive	Very often (80–99%)
Non-obstructive azoospermia	Very often (80–99%)
Undescended testes	Very often (80–99%)
Previous menstrual periods stop	Often (30–79%)
Small uterus	Often (30–79%)
Underdeveloped ovary	Often (30–79%)
Infertility	Sometimes (5–29%)

Abnormality of the endocrine system

Trait	How often it is seen
Decreased circulating luteinizing hormone level	Always
Decreased serum testosterone level	Always
Hypogonadotropic hypogonadism	Always
Absence of pubertal development	Very often (80–99%)
Absence of secondary sex characteristics	Very often (80–99%)
Decreased function of male gonad	Very often (80–99%)
Female hypogonadism	Very often (80–99%)
Delayed puberty	Often (30–79%)
Decreased circulating follicle stimulating hormone concentration	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Delayed bone maturation	Very often (80–99%)
Osteopenia	Often (30–79%)
Osteoporosis	Often (30–79%)
Hypermobility of all joints	Sometimes (5–29%)
Permanent flexion of the finger or toe	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Abnormal dentition	Sometimes (5–29%)
Cleft palate	Sometimes (5–29%)
Depressed nasal bridge	Sometimes (5–29%)
Lost smell	Sometimes (5–29%)

Abnormality of the breast

Trait	How often it is seen
Underdeveloped breasts	Very often (80–99%)
Wide-spaced nipples	Very often (80–99%)
Enlarged male breast	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Limited armpit hair	Always
Sparse pubic hair	Always
Sparse body hair	Very often (80–99%)

Abnormality of the nervous system

Trait	How often it is seen
Anxiety	Often (30–79%)
Depression	Often (30–79%)
Intellectual disability, mild	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Eunuchoid habitus	Very often (80–99%)
Abnormality of body height	Often (30–79%)

Abnormality of the ear

Trait	How often it is seen
Congenital sensorineural hearing impairment	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Wide-set eyes	Sometimes (5–29%)

Abnormality of the voice

Trait	How often it is seen
Abnormality of the voice	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TAC3 and how often each is seen. Find out more at hpo.jax.org.

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