{ "url": "https://dantelabs.com/genes/slfn14", "gene": { "slug": "slfn14", "symbol": "SLFN14", "name": "schlafen family member 14", "hgnc": "HGNC:32689", "summary": null, "location": "17q12", "locusType": "gene with protein product", "aliases": [], "previousSymbols": [], "ensemblId": "ENSG00000236320", "entrezId": 342618, "omim": [ "614958" ], "uniprot": [ "P0C7P3" ], "model": { "build": "GRCh38", "release": "v1.5", "chrom": "17", "start": 35543985, "end": 35560819, "strand": "-", "ensemblTranscript": "ENST00000674182.1", "refseqTranscript": "NM_001129820.2", "ensemblProtein": "ENSP00000501524.1", "refseqProtein": "NP_001123292.1", "exons": [ { "start": 35543985, "end": 35549073 }, { "start": 35552730, "end": 35553444 }, { "start": 35554576, "end": 35554704 }, { "start": 35557003, "end": 35558106 }, { "start": 35559727, "end": 35559805 }, { "start": 35560767, "end": 35560819 } ], "cds": { "start": 35548239, "end": 35558062 } }, "grch37": { "build": "GRCh37", "release": "87", "chrom": 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"ENSG00000108733", "biotype": "protein_coding", "start": 35574795, "end": 35578863, "strand": "-", "slug": "pex12" }, { "symbol": "AP2B1", "ensemblId": "ENSG00000006125", "biotype": "protein_coding", "start": 35578046, "end": 35726417, "strand": "+", "slug": "ap2b1" }, { "symbol": "RASL10B", "ensemblId": "ENSG00000270885", "biotype": "protein_coding", "start": 35731639, "end": 35743521, "strand": "+", "slug": "rasl10b" }, { "symbol": "GAS2L2", "ensemblId": "ENSG00000270765", "biotype": "protein_coding", "start": 35744511, "end": 35753260, "strand": "-", "slug": "gas2l2" }, { "symbol": "MMP28", "ensemblId": "ENSG00000271447", "biotype": "protein_coding", "start": 35756249, "end": 35795719, "strand": "-", "slug": "mmp28" }, { "symbol": "PGBDF", "ensemblId": "ENSG00000270806", "biotype": "protein_coding", "start": 35760887, "end": 35765079, "strand": "+", "slug": "pgbdf" }, { "symbol": "TAF15", "ensemblId": "ENSG00000270647", "biotype": "protein_coding", "start": 35809475, "end": 35864615, "strand": "+", "slug": "taf15" }, { "symbol": "HEATR9", "ensemblId": "ENSG00000270379", "biotype": "protein_coding", "start": 35854946, "end": 35868891, "strand": "-", "slug": "heatr9" }, { "symbol": "CCL5", "ensemblId": "ENSG00000271503", "biotype": "protein_coding", "start": 35871491, "end": 35880793, "strand": "-", "slug": "ccl5" }, { "symbol": "RDM1", "ensemblId": "ENSG00000278023", "biotype": "protein_coding", "start": 35918066, "end": 35930794, "strand": "-", "slug": "rdm1" }, { "symbol": "LYZL6", "ensemblId": "ENSG00000275722", "biotype": "protein_coding", "start": 35934518, "end": 35943713, "strand": "-", "slug": "lyzl6" }, { "symbol": "CCL16", "ensemblId": "ENSG00000275152", "biotype": "protein_coding", "start": 35976192, "end": 35981580, "strand": "-", "slug": "ccl16" }, { "symbol": "CCL14", "ensemblId": "ENSG00000276409", "biotype": "protein_coding", "start": 35983288, "end": 35987033, "strand": "-", "slug": "ccl14" }, { "symbol": "CCL15-CCL14", "ensemblId": "ENSG00000275688", "biotype": "protein_coding", "start": 35983656, "end": 36001621, "strand": "-", "slug": "ccl15-ccl14" }, { "symbol": "CCL15", "ensemblId": "ENSG00000275718", "biotype": "protein_coding", "start": 35988463, "end": 36002119, "strand": "-", "slug": "ccl15" }, { "symbol": "CCL23", "ensemblId": "ENSG00000274736", "biotype": "protein_coding", "start": 36013056, "end": 36017979, "strand": "-", "slug": "ccl23" } ], "truncated": false }, "reports": [ { "slug": "inherited-thrombocytopenias", "name": "Inherited Thrombocytopenias", "diseases": [ { "mondoId": "MONDO:0100241", "name": "Inherited Thrombocytopenia", "genes": 33, "inheritance": null, "description": "A group of conditions causing a lifelong low platelet count, linked to genes such as MYH9, ANKRD26, ETV6, WAS, MPL, RBM8A, GATA1 and MECOM, and inherited in dominant, recessive or X-linked patterns.", "management": "A genetic diagnosis avoids misdiagnosis as immune thrombocytopenia, with unnecessary steroids or spleen removal, and guides monitoring for related kidney, hearing or blood problems.", "evidence": { "gencc": [ "Labcorp Genetics (formerly Invitae)", "PanelApp Australia" ], "clingen": "Moderate", "acmgSf": false, "inheritance": [ "autosomal-dominant" ] }, "sameAsReport": false, "broad": false } ], "url": "https://dantelabs.com/conditions/inherited-thrombocytopenias" } ], "pharmacogenomics": [], "traits": [], "phenotypes": [ { "slug": "menorrhagia", "name": "Abnormally heavy bleeding during menstruation", "systems": [ "abnormality-of-blood-and-blood-forming-tissues", "abnormality-of-the-genitourinary-system" ], "url": "https://dantelabs.com/traits/menorrhagia" }, { "slug": "epistaxis", "name": "Bloody nose", "systems": [ "abnormality-of-blood-and-blood-forming-tissues", "abnormality-of-head-or-neck" ], "url": "https://dantelabs.com/traits/epistaxis" }, { "slug": "bruising-susceptibility", "name": "Bruising susceptibility", "systems": [ "abnormality-of-blood-and-blood-forming-tissues", "abnormality-of-the-cardiovascular-system", "abnormality-of-the-integument" ], "url": "https://dantelabs.com/traits/bruising-susceptibility" }, { "slug": "thrombocytopenia", "name": "Low platelet count", "systems": [ "abnormality-of-blood-and-blood-forming-tissues" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/thrombocytopenia" } ], "related": [ { "slug": "actb", "symbol": "ACTB", "name": "actin beta", "shared": 1, "url": "https://dantelabs.com/genes/actb" }, { "slug": "actn1", "symbol": "ACTN1", "name": "actinin alpha 1", "shared": 1, "url": "https://dantelabs.com/genes/actn1" }, { "slug": "adamts13", "symbol": "ADAMTS13", "name": "ADAM metallopeptidase with thrombospondin type 1 motif 13", "shared": 1, "url": "https://dantelabs.com/genes/adamts13" }, { "slug": "ankrd26", "symbol": "ANKRD26", "name": "ankyrin repeat domain 26", "shared": 1, "url": "https://dantelabs.com/genes/ankrd26" }, { "slug": "arpc1b", "symbol": "ARPC1B", "name": "actin related protein 2/3 complex subunit 1B", "shared": 1, "url": "https://dantelabs.com/genes/arpc1b" }, { "slug": "cdc42", "symbol": "CDC42", "name": "cell division cycle 42", "shared": 1, "url": "https://dantelabs.com/genes/cdc42" }, { "slug": "cycs", "symbol": "CYCS", "name": "cytochrome c, somatic", "shared": 1, "url": "https://dantelabs.com/genes/cycs" }, { "slug": "diaph1", "symbol": "DIAPH1", "name": "diaphanous related formin 1", "shared": 1, "url": "https://dantelabs.com/genes/diaph1" }, { "slug": "etv6", "symbol": "ETV6", "name": "ETS variant transcription factor 6", "shared": 1, "url": "https://dantelabs.com/genes/etv6" }, { "slug": "fli1", "symbol": "FLI1", "name": "Fli-1 proto-oncogene, ETS transcription factor", "shared": 1, "url": "https://dantelabs.com/genes/fli1" }, { "slug": "fyb1", "symbol": "FYB1", "name": "FYN binding protein 1", "shared": 1, "url": "https://dantelabs.com/genes/fyb1" }, { "slug": "gale", "symbol": "GALE", "name": "UDP-galactose-4-epimerase", "shared": 1, "url": "https://dantelabs.com/genes/gale" } ], "sources": { "bundleId": "2026.10.17-8666dff2", "panel": "2026-10-17", "acmgSf": "SF v3.2" }, "locusKind": "proteinCoding" }, "variants": { "total": 0, "url": null, "items": [] } }