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Trait

High blood HDL level

Clinical name: Elevated circulating HDL-C concentration

The concentration of high-density lipoprotein cholesterol in the blood circulation is above the upper limit of normal.

HPO HP:0012184

Summary

Also called
Elevated high-density lipoprotein cholesterol concentration, Elevated high-density lipoprotein cholesterol level, Elevated high-density lipoprotein cholesterol level in blood, Hyperalphalipoproteinemia, Increased circulating high-density lipoprotein levels, Increased high-density lipoprotein cholesterol concentration, Increased high-density lipoprotein cholesterol level, Increased high-density lipoprotein cholesterol level in blood
Body system
Laboratory abnormality

3 genes linked to High blood HDL level

Changes in these genes cause rare conditions in which High blood HDL level is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
LIPClipase C, hepatic typeAlwaysIn 2 conditions
APOC3apolipoprotein C3Not recordedIn 1 condition
CETPcholesteryl ester transfer proteinNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal circulating HDL-C concentrationHyperlipoproteinemia

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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