Traits

Traits linked to KRT74

keratin 74

The Human Phenotype Ontology links 40 traits to KRT74, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the integument

Trait	How often it is seen
Afro-textured hair	Always
Brittle hair	Always
Coarse hair	Always
Detachment of nail	Always
Dry hair	Always
Poor fingernail formation	Always
Poor toenail formation	Always
Slow-growing hair	Always
Abnormality of hair texture	Very often (80–99%)
Fine hair	Very often (80–99%)
Hyperkeratosis	Often (30–79%)
Loss of hair color	Often (30–79%)
Parakeratosis	Often (30–79%)
Thickening of upper layer of skin	Often (30–79%)
Itching	Sometimes (5–29%)
Scaling skin	Sometimes (5–29%)
Sparse body hair	Sometimes (5–29%)
Abnormality of the axillary hair	Not recorded
Abnormality of the nail	Not recorded
Abnormality of the pubic hair	Not recorded
Absent facial hair	Not recorded
Generalized hypotrichosis	Not recorded
Hair loss	Not recorded
Lack of sweating or excessive sweating	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Sparse eyebrow	Always
Sparse eyelashes	Always
Sparse scalp hair	Always
Slow-growing scalp hair	Very often (80–99%)
Absence of scalp hair	Often (30–79%)
Hay fever	Sometimes (5–29%)
Limited hair on end of eyebrow	Sometimes (5–29%)
Abnormal dentition	Not recorded
Abnormal eyelashes	Not recorded
Abnormality of the eyebrow	Not recorded

Abnormality of the eye

Trait	How often it is seen
Abnormality of the pupil	Sometimes (5–29%)
Clouding of the lens of the eye	Sometimes (5–29%)
Cross-eyed	Sometimes (5–29%)
Retina issue	Sometimes (5–29%)

Abnormal cellular phenotype

Trait	How often it is seen
Increased circulating IgE concentration	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Baby eczema	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to KRT74 and how often each is seen. Find out more at hpo.jax.org.

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