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Gene

KLF4

KLF transcription factor 4

Summary

Cytogenetic location
9q31.2
Coordinates
Chromosome 9: 107,484,852–107,489,769 (GRCh38)
Exons
5 exons across 4.9 kb
Protein
479 amino acids
Also known as
EZF, GKLF
MANE Select transcript
ENST00000374672.5NM_004235.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Palmoplantar Keratodermas and Pachyonychia Congenita

    • Hereditary palmoplantar keratoderma

      Inherited thickening of the palms and soles, including pachyonychia congenita, mal de Meleda, Nagashima-type and Bothnian keratodermas, keratitis-ichthyosis-deafness syndrome, and the CTSC-related Papillon-Lefèvre and Haim-Munk syndromes.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Diagnosis guides foot care and pain management; for CTSC-related forms early dental treatment protects the teeth, and GJB2-related forms warrant a hearing check.

How KLF4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 9, with a bracket where KLF4 sits. KLF4 and 2 genes near it on chromosome 9, from 106,987,311 to 107,987,310.Chromosome 99q31.2p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.3107 Mb107.2 Mb107.4 Mb107.6 Mb107.8 MbZNF462: 106,862,286–107,013,634, forward strandZNF462RAD23B: 107,283,137–107,332,192, forward strandRAD23BKLF4: 107,484,852–107,489,769, reverse strandKLF4Diagram of KLF4: 5 exons on the reverse strand of chromosome 9Exon 5: 107,484,852–107,485,926, 1,075 basesExon 4: 107,487,028–107,487,192, 165 basesExon 3: 107,487,295–107,488,267, 973 basesExon 2: 107,488,930–107,489,050, 121 basesExon 1: 107,489,168–107,489,769, 602 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.9 kb of the gene's 4.9 kb; 1,440 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KLF4 gene: KLF transcription factor 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/klf4

Vancouver

Dante Labs. KLF4 gene: KLF transcription factor 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/klf4

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