Traits

Traits linked to KIF1C

kinesin family member 1C

The Human Phenotype Ontology links 35 traits to KIF1C, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Difficulty articulating speech	Always
Inability to coordinate movements when walking	Always
Lack of coordination of movement	Always
Abnormal cerebral white matter morphology	Very often (80–99%)
Head titubation	Very often (80–99%)
Increased reflexes	Very often (80–99%)
Muscle twitch	Very often (80–99%)
Overactive lower leg reflex	Very often (80–99%)
Spastic ataxia	Very often (80–99%)
Tremor	Very often (80–99%)
Babinski sign	Often (30–79%)
Chorea	Often (30–79%)
Clonus	Often (30–79%)
Erratic myoclonus	Often (30–79%)
Peripheral demyelination	Often (30–79%)
Titubation	Often (30–79%)
Abnormal pyramidal sign	Sometimes (5–29%)
Degeneration of cerebellum	Sometimes (5–29%)
Degeneration of cerebrum	Sometimes (5–29%)
Global developmental delay	Sometimes (5–29%)
Intellectual disability, mild	Sometimes (5–29%)
Intention tremor	Sometimes (5–29%)
Toe walking	Sometimes (5–29%)
Unsteady walk	Sometimes (5–29%)
Peripheral neuropathy	Rarely (1–4%)

Abnormality of head or neck

Trait	How often it is seen
Failure of development of between one and six teeth	Very often (80–99%)
Abnormally small head	Often (30–79%)
Wry neck	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Distal muscle wasting	Often (30–79%)
Frequent falls	Often (30–79%)
Involuntary muscle stiffness, contraction, or spasm	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Horizontal nystagmus	Very often (80–99%)
Decreased clarity of vision	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Abnormal rhythmic movements of ankle	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Short stature	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to KIF1C and how often each is seen. Find out more at hpo.jax.org.

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