Traits

Traits linked to KIF15

kinesin family member 15

The Human Phenotype Ontology links 67 traits to KIF15, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Always
Bulbous nose	Always
Cleft palate	Always
Downward slanting of the opening between the eyelids	Always
Pierre-Robin sequence	Always
Receding chin	Always
Wide mouth	Always
Abnormal facial shape	Often (30–79%)
Coarse facial features	Often (30–79%)
Almond shaped eyes	Sometimes (5–29%)
Dark circles around the eyes	Sometimes (5–29%)
Dental crowding	Sometimes (5–29%)
Downturned corners of mouth	Sometimes (5–29%)
Drooling	Sometimes (5–29%)
Full lips	Sometimes (5–29%)
Full lower lip	Sometimes (5–29%)
Midface retrusion	Sometimes (5–29%)
Nasal tip, upturned	Sometimes (5–29%)
Round face	Sometimes (5–29%)
Scaphocephaly	Sometimes (5–29%)
Short opening between the eyelids	Sometimes (5–29%)
Smooth philtrum	Sometimes (5–29%)
Thin red part of the upper lip	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Absent speech development	Often (30–79%)
Behavioral abnormality	Often (30–79%)
Epilepsy	Often (30–79%)
Intellectual disability	Often (30–79%)
Severe global developmental delay	Often (30–79%)
Sleep-wake cycle disturbance	Often (30–79%)
Agenesis of corpus callosum	Sometimes (5–29%)
Inappropriate crying	Sometimes (5–29%)
More active than typical	Sometimes (5–29%)
Poor speech	Sometimes (5–29%)
Self-injurious behavior	Sometimes (5–29%)
Stereotypical body rocking	Sometimes (5–29%)
Teeth grinding	Sometimes (5–29%)
Tongue thrusting	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Curvature of digit	Always
Short fingers or toes	Often (30–79%)
Acromesomelia	Sometimes (5–29%)
Cone-shaped end part of finger bones	Sometimes (5–29%)
Short innermost pinkie finger bone	Sometimes (5–29%)
Short proximal phalanx of the 2nd finger	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Absent ear canal	Always
Hearing impairment	Always
Low-set ears	Sometimes (5–29%)
Recurrent middle ear infection	Sometimes (5–29%)
Small ears	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Small nail	Often (30–79%)
Dry skin	Sometimes (5–29%)
Poor nail formation	Sometimes (5–29%)
Spinal dimple	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low platelet count	Always
Megakaryocytopenia	Always
Low number of red blood cells or hemoglobin	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Abnormally small eyeball	Always
Cross-eyed	Sometimes (5–29%)
Wide-set eyes	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Permanent flexion of the finger or toe	Often (30–79%)
Decreased muscle tone in infant	Sometimes (5–29%)
Delayed bone maturation	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight in infancy	Often (30–79%)
Growth delay as children	Often (30–79%)
Short stature	Often (30–79%)

Abnormality of the breast

Trait	How often it is seen
Small nipples	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
An opening in the wall separating the top two chambers of the heart	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties in infancy	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to KIF15 and how often each is seen. Find out more at hpo.jax.org.

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