Gene
ICOSLG
inducible T cell costimulator ligand
- HGNC 17087(opens in a new tab)
- Ensembl gene ENSG00000160223(opens in a new tab)
- NCBI Gene 23308(opens in a new tab)
Summary
- Cytogenetic location
- 21q22.3
- Coordinates
- Chromosome 21: 44,222,991–44,240,943 (GRCh38)
- Exons
- 7 exons across 18 kb
- Protein
- 302 amino acids
- Also known as
- KIAA0653, GL50, B7-H2, B7RP-1, B7H2, B7RP1, ICOS-L, CD275, B7h
- Previous symbols
- ICOSL
- MANE Select transcript
- ENST00000407780.8NM_015259.6
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Other Inborn Errors of Immunity
- Immunodeficiency Disease
One of 170 genes linked to it
Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.
- ClinGen rates the link moderate
What knowing changes
HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD
How ICOSLG is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 7.1 kb of the gene's 18 kb; 909 of those bases code for the protein.
How a genome test reads ICOSLG
2
positions in ICOSLG where ClinVar classes a change as pathogenic or likely pathogenic
2 of them (100%) fall in regions short reads find hard.
- Low mappability (2 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
- Segmental duplications (2 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.
A whole genome covers all 18 kb of ICOSLG, introns included, not only the 7.1 kb of exons.
Traits linked to ICOSLG
The Human Phenotype Ontology lists these as features of the rare conditions ICOSLG can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). ICOSLG gene: inducible T cell costimulator ligand. Retrieved 16 October 2026, from https://dantelabs.com/genes/icoslg
Dante Labs. ICOSLG gene: inducible T cell costimulator ligand [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/icoslg
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