Traits

Traits linked to FGD4

FYVE, RhoGEF and PH domain containing 4

The Human Phenotype Ontology links 19 traits to FGD4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Absent reflexes	Always
Decreased motor nerve conduction velocity	Always
Decreased number of peripheral myelinated nerve fibers	Always
Motor delay	Always
Numbness	Always
Onion bulb formation	Always
Unsteady walk	Always
Decreased reflex response	Not recorded
Decreased sensation in extremities	Not recorded
Peripheral hypomyelination	Not recorded
Waddling gait	Not recorded

Abnormality of limbs

Trait	How often it is seen
Club feet	Often (30–79%)
Small hypothenar eminence	Often (30–79%)
Small thenar eminence	Often (30–79%)
Decreased arm strength	Not recorded
Distal lower limb muscle weakness	Not recorded
High-arched foot	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Scoliosis	Often (30–79%)
Distal lower limb amyotrophy	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to FGD4 and how often each is seen. Find out more at hpo.jax.org.

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