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Trait

Small hypothenar eminence

Reduced muscle mass on the ulnar side of the palm, that is, reduction in size of the hypothenar eminence.

HPO HP:0010487

Summary

Also called
Hypoplasia of the hypothenar eminence, Hypothenar hypoplasia
Body system
Abnormality of limbsAbnormality of the musculoskeletal system

6 genes linked to Small hypothenar eminence

Changes in these genes cause rare conditions in which Small hypothenar eminence is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
DHRS3dehydrogenase/reductase 3AlwaysIn 1 condition
NDC1NDC1 transmembrane nucleoporinAlwaysIn 1 condition
TBX5T-box transcription factor 5AlwaysIn 1 condition
EIF4A3eukaryotic translation initiation factor 4A3Very often (80–99%)In 1 condition
FGD4FYVE, RhoGEF and PH domain containing 4Often (30–79%)In 1 condition
RPL11ribosomal protein L11Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the hypothenar eminence

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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