Traits

Traits linked to CENPF

centromere protein F

The Human Phenotype Ontology links 30 traits to CENPF, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the eye

Trait	How often it is seen
Abnormally small eyeball	Not recorded
Cat eye	Not recorded
Clouding of the lens of the eye	Not recorded
Cornea of eye less than 10mm in diameter	Not recorded
Deeply set eye	Not recorded
Hardening of skin and connective tissue	Not recorded
Optic nerve hypoplasia	Not recorded
Peters anomaly	Not recorded
Wide-set eyes	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Not recorded
Cleft palate	Not recorded
Little lower jaw	Not recorded
Prominent nasal bridge	Not recorded
Short columella	Not recorded
Wide mouth	Not recorded
Wide nasal bridge	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Agenesis of corpus callosum	Not recorded
Cerebellar vermis hypoplasia	Not recorded
Small cerebellum	Not recorded
Too much cerebrospinal fluid in the brain	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Absence or narrowing of first part of small bowel	Not recorded
Intestinal malrotation	Not recorded
Jejunal atresia	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Accessory spleen	Rarely (1–4%)
Retinal vascular tortuosity	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Bilateral renal hypoplasia	Not recorded
Hydronephrosis	Not recorded

Abnormality of limbs

Trait	How often it is seen
Preaxial polydactyly	Rarely (1–4%)

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Muscle tissue disease	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CENPF and how often each is seen. Find out more at hpo.jax.org.

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