Traits

Traits linked to CARD11

caspase recruitment domain family member 11

The Human Phenotype Ontology links 27 traits to CARD11, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the immune system

Trait	How often it is seen
Baby eczema	Always
Decreased immune function	Always
Decreased specific antibody response to unconjugated polysaccharide vaccine	Always
Pneumocystis jirovecii pneumonia	Always
Recurrent infections	Always
Recurrent respiratory infections	Always
Asthma	Often (30–79%)
Food allergy	Often (30–79%)
Pneumonia	Often (30–79%)
Disseminated molluscum contagiosum	Sometimes (5–29%)
Severe cytomegalovirus infection	Sometimes (5–29%)

Abnormal cellular phenotype

Trait	How often it is seen
Agammaglobulinemia	Always
Decreased antigen-specific T cell proliferation	Always
Decreased circulating antibody level	Always
Decreased circulating IgA concentration	Always
Decreased circulating IgM concentration	Often (30–79%)
Increased circulating IgE concentration	Often (30–79%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Decreased regulatory T cell proportion	Always
Increased total B cell count	Always
Low blood monocyte number	Always
Lymphoid hyperplasia	Always
High blood eosinophil count	Very often (80–99%)

Abnormality of the digestive system

Trait	How often it is seen
Chronic diarrhea	Sometimes (5–29%)
Colonic eosinophilia	Sometimes (5–29%)
Ulcerative colitis	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Increased spleen size	Always

Abnormality of the respiratory system

Trait	How often it is seen
Permanent enlargement of the airways of the lungs	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CARD11 and how often each is seen. Find out more at hpo.jax.org.

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