Traits

Traits linked to BNC2

basonuclin zinc finger protein 2

The Human Phenotype Ontology links 28 traits to BNC2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the genitourinary system

Trait	How often it is seen
Chronic kidney disease	Very often (80–99%)
Congenital posterior urethral valve	Very often (80–99%)
Frequent urinary tract infections	Very often (80–99%)
Bladder outlet obstruction	Often (30–79%)
Hydronephrosis	Often (30–79%)
Narrowing of the urethra	Often (30–79%)
Vesicoureteral reflux	Often (30–79%)
Bladder diverticulum	Sometimes (5–29%)
Constant urination	Sometimes (5–29%)
Dilatation of the bladder	Sometimes (5–29%)
Fetal megacystis	Sometimes (5–29%)
Loss of bladder control	Sometimes (5–29%)
Pyelonephritis	Sometimes (5–29%)
Renal dysplasia	Sometimes (5–29%)
Renal failure	Sometimes (5–29%)
Stage 5 chronic kidney disease	Sometimes (5–29%)
Dull burning sensation with urination	Rarely (1–4%)
Urinary retention	Rarely (1–4%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Fetal pyelectasis	Sometimes (5–29%)
Low levels of amniotic fluid	Rarely (1–4%)

Laboratory abnormality

Trait	How often it is seen
Blood in urine	Sometimes (5–29%)
High urine protein levels	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Potter facies	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Abdominal pain	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Lumbago	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Lethargy	Rarely (1–4%)

Abnormality of the respiratory system

Trait	How often it is seen
Absent/small lungs	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to BNC2 and how often each is seen. Find out more at hpo.jax.org.

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