Traits

Traits linked to AGGF1

angiogenic factor with G-patch and FHA domains 1

The Human Phenotype Ontology links 31 traits to AGGF1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the cardiovascular system

Trait	How often it is seen
Poorly functioning veins	Very often (80–99%)
Strawberry mark	Very often (80–99%)
Blood clot in artery of lung	Often (30–79%)
Abnormal tricuspid valve morphology	Sometimes (5–29%)
Abnormality of lung artery	Sometimes (5–29%)
An opening in the wall separating the top two chambers of the heart	Sometimes (5–29%)
Cardiac failure	Sometimes (5–29%)
Patent ductus arteriosus	Sometimes (5–29%)
Peripheral arteriovenous fistula	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Blood clot in vein	Often (30–79%)
Gastrointestinal bleeding	Often (30–79%)
Hypercoagulability	Sometimes (5–29%)
Internal bleeding	Sometimes (5–29%)
Microcytic anemia	Sometimes (5–29%)
Prolonged bleeding time	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Abnormality of the skull	Sometimes (5–29%)
Abnormally small head	Sometimes (5–29%)
Big calvaria	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Blood in urine	Sometimes (5–29%)
Fluid retention	Sometimes (5–29%)
Hydrops fetalis	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Left and right leg differ in length or width	Very often (80–99%)
Unequal size of arms	Very often (80–99%)

Abnormality of the digestive system

Trait	How often it is seen
Accumulation of fluid in the abdomen	Sometimes (5–29%)
Enlarged liver	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Abnormally shaped skeletal	Very often (80–99%)
Bacterial infection of skin	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormality of the menstrual cycle	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Intellectual disability	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Respiratory function loss	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Tall stature	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to AGGF1 and how often each is seen. Find out more at hpo.jax.org.

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