Dante Labs vs Sequencing.com
Dante Labs vs Sequencing.com: the same genome, a different idea of what's included.
Sequencing.com and Dante Labs both sequence your whole genome at 30X. Sequencing.com sells the sequencing, then most health analyses app by app. Dante includes 810+ physician-ready reports with Premium. Here is how they compare, with sources.
Where the difference lies
Two ways to pay for what your genome means.
Sequencing.com · Whole genome, 30X
Kit first, analyses app by app
The kit includes sequencing, your raw files and a few free basic apps. Most health analyses are separate apps from a marketplace, each bought and read on its own.
Dante Labs · Whole genome, 30X
Reports included in your plan
810+ physician-ready reports with Premium, classified against ACMG guidelines and read from your whole genome, then updated as the science advances without a new sample.
Both read the whole genome.
The difference is how you get to what it means.
Side by side
Sequencing.com and Dante Labs, point by point.
What each test reads, the health reports it gives you, what you get back and what it costs.
| Sequencing.comWhole genome, 30X | Dante LabsWhole genome, 30X | |
|---|---|---|
| Method | Whole genome sequencing at 30X | Whole genome sequencing at 30X |
| Health | ||
| Health reports | Basic apps free; most health apps bought one by one | 810+ physician-ready reports with Premium |
| Drug response | a separate paid app | Read from your whole genome, no second test |
| Clinical use | results not clinical; confirm before medical decisions | Physician-ready, classified against ACMG guidelines |
| Reports over time | Depends on each app | Updated as the science advances, no new sample |
| Uploading other data | Free upload from 23andMe, AncestryDNA and others | Upload 23andMe, AncestryDNA or similar data |
| Your data and the kit | ||
| Raw data | FASTQ, BAM or CRAM, and VCF | Full FASTQ, BAM and VCF, always free to download |
| Lab | CLIA-certified, CAP-accredited US lab, operator not named | CLIA-certified, CAP-accredited partner labs; ISO 15189 |
| Sample | Cheek swab (cheek epithelial cells) | blood spot, collected at home |
| Bacterial DNA in the sample | Cheek swabs carry mouth bacteria: a median of about 14% of reads weren't human, though in that study it did not change diagnostic results¹ | Blood normally carries little bacterial DNA: in 9,770 healthy people, 84% had no microbes in their blood² |
| ResultsAfter the lab receives the sample | 10–12 weeks; faster for a fee | Typically 6–8 weeks |
| Price | US kit about $399; most "health apps" extra | Kit with Core: $449. Premium, for all 810+ reports: $99 more the first year, then $99 a year |
| Order your kit |
Sequencing.com details are from its website and independent reviews (July and August 2026). Products and prices change, so check Sequencing.com for its current offer. ¹ Kumar et al., Frontiers in Genetics, 2023 (765 cheek swab and saliva genomes). ² Tan et al., Nature Microbiology, 2023 (venous blood from 9,770 healthy people; home blood spots were not studied).
Common ground
What a 30X genome gives you, either way.
Both tests sequence your whole genome at 30X: each position is read about 30 times on average, coding and non-coding, so rare and family-specific variants are read wherever they are. Both let you keep your sequencing files, which stay useful as the science moves on.
So the choice is not about how much of your DNA is read. It is about what happens next: who interprets it, to what standard, and what that costs you over time.
Reports
Reports, and what they cost over time.
Sequencing.com's kit includes a few free apps, such as an ancestry overview and basic traits. Health analyses, such as carrier status or drug response, are separate apps from its marketplace, priced one by one, and built by different developers.
Dante's Premium plan includes 810+ physician-ready reports covering hereditary risk, drug response and carrier status. Every report is classified against ACMG guidelines, the standard clinical geneticists use, so a doctor can work from it.
A sequenced genome keeps answering new questions. Dante reads yours again as new variant–disease links are published, and updates your reports without a new sample.
Choosing
When Sequencing.com is the better fit.
Sequencing.com's kit costs less up front, and it offers faster results for an extra fee. If you want your genome files and one or two specific analyses, and are happy to choose and judge each app yourself, it is a reasonable choice.
If you want a complete set of physician-ready reports from the start, interpreted to one clinical standard and kept up to date, that is what Dante is built for.
Questions
Dante Labs vs Sequencing.com: common questions
Yes. Both offer whole genome sequencing at a 30X average, which reads every position of your genome about 30 times.
Sequencing.com's kit includes a few free basic apps; most health analyses are paid apps bought separately. Dante's Premium plan includes 810+ physician-ready reports.
Yes. Data from 23andMe, AncestryDNA or similar providers can be uploaded for Dante's reports and interpretation. A chip file only holds the positions the chip read, so it cannot stand in for a sequenced genome.
Sequencing.com's standard turnaround is reported at 10–12 weeks, with faster options for a fee. Dante's whole genome results typically arrive 6–8 weeks after the lab receives the sample, with email updates at each step.
You control your data: download, delete or anonymise it at any time. Dante does not sell personal or genomic data, and nothing is shared without your explicit consent. Data handling follows GDPR and HIPAA.
Method
How we compared.
This page is written by Dante Labs. Sequencing.com details are from its website and the independent reviews below; Dante Labs details are from this site. Sources:
- Sequencing.com: Whole Genome Sequencing 30x
- KnowYourDNA: Sequencing.com review (August 2026)
- GenomeTesting.org: Sequencing.com review (July 2026)
- Kumar et al., Frontiers in Genetics (2023): Microbial contamination and composition of oral samples subjected to clinical whole genome sequencing
- Tan et al., Nature Microbiology (2023): No evidence for a common blood microbiome based on a population study of 9,770 healthy humans
Last reviewed 18 October 2026.
Your whole genome, with the reports included.
810+ physician-ready reports with Premium, from one sample collected at home.
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