Tylosis with oesophageal cancer (RHBDF2)
Autosomal dominant
Thickening of the palms and soles from childhood, with a strongly increased risk of oesophageal squamous cell carcinoma in adulthood.
What a diagnosis changes
Guidelines advise regular endoscopic surveillance from early adulthood, which can find cancers at a treatable stage; avoiding smoking and alcohol is also advised.
Genes analysed
Also known as
Bennion-Patterson syndrome; howel-Evans syndrome; Howell-Evans syndrome; keratosis palmaris et plantaris with esophageal cancer; keratosis palmoplantaris with esophageal cancer; keratosis palmoplantaris-esophageal carcinoma syndrome; palmoplantar hyperkeratosis-esophageal carcinoma syndrome; Toc; tylosis - oesophageal carcinoma; tylosis with esophageal cancer; tylosis-oesophageal carcinoma syndrome
