Trait

Decreased circulating terminal complement component concentration

Concentration below the lower limit of normal of one or more components of the the terminal membrane attack complex (MAC) portion of complement, which represents the lytic, pore-forming part of the system. The MAC comprises seven components: C5b, C6, C7, C8 (a heterotrimer composed of C8alpha, C8beta and C8gamma) and multiple copies of C9.

HPO HP:0033057

Also called: Decreased serum terminal complement component
Body system: Abnormality of the immune system

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/decreased-circulating-terminal-complement-component-concentration.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

Read the genes linked to Decreased circulating terminal complement component concentration, and the rest of your genome, with one test.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test

0 genes linked to Decreased circulating terminal complement component concentration

The Human Phenotype Ontology links no gene to Decreased circulating terminal complement component concentration itself. The narrower traits below list theirs.

Narrower traits

Broader traits

Reduced circulating complement concentration

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

One test. A lifetime of answers.