Traits

Traits linked to TUBA8

tubulin alpha 8

The Human Phenotype Ontology links 23 traits to TUBA8, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Abnormality of the nervous system	Very often (80–99%)
Absent speech development	Very often (80–99%)
Colpocephaly	Very often (80–99%)
Decreased reflex response	Very often (80–99%)
Epilepsy	Very often (80–99%)
More grooves in brain	Very often (80–99%)
Severe global developmental delay	Very often (80–99%)
Agenesis of corpus callosum	Often (30–79%)
Grand mal seizures	Often (30–79%)
Dysplastic corpus callosum	Sometimes (5–29%)
Infantile spasms	Sometimes (5–29%)
Small brainstem	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Large platelets	Very often (80–99%)
Low platelet count	Very often (80–99%)
Macrothrombocytopenia	Very often (80–99%)
Platelet anisocytosis	Often (30–79%)
Bloody nose	Sometimes (5–29%)
Bruising susceptibility	Sometimes (5–29%)
Prolonged bleeding after dental extraction	Sometimes (5–29%)
Prolonged bleeding after surgery	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Optic nerve hypoplasia	Very often (80–99%)

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormal uterus bleeding	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone, in neonatal onset	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TUBA8 and how often each is seen. Find out more at hpo.jax.org.

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