Traits

Traits linked to TSHZ3

teashirt zinc finger homeobox 3

The Human Phenotype Ontology links 40 traits to TSHZ3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Very often (80–99%)
Broad columella	Often (30–79%)
Decreased volume of lip	Often (30–79%)
High forehead	Often (30–79%)
Limited hair on end of eyebrow	Often (30–79%)
Long face	Often (30–79%)
Receding chin	Often (30–79%)
Sparse or absent eyelashes	Often (30–79%)
Underdeveloped tissue around nostril	Often (30–79%)
Only one upper front tooth	Sometimes (5–29%)
Wide mouth	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Absence of part of skin at birth	Very often (80–99%)
Atypical nail growth	Often (30–79%)
Dry skin	Often (30–79%)
Fine hair	Often (30–79%)
Sparse hair	Often (30–79%)
Thin skin	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Curvature of little finger	Very often (80–99%)
Finger syndactyly	Often (30–79%)
Fused toes	Often (30–79%)
Toe curvature	Often (30–79%)
Dislocated hip since birth	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Very often (80–99%)
Growth delay	Very often (80–99%)
Prenatal growth deficiency	Very often (80–99%)
Wasting syndrome	Very often (80–99%)

Abnormality of the genitourinary system

Trait	How often it is seen
Hypospadias	Very often (80–99%)
Undescended testes	Often (30–79%)
Cleft of scrotum	Sometimes (5–29%)

Abnormality of the breast

Trait	How often it is seen
Accessory nipple	Often (30–79%)
Wide-spaced nipples	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormal cardiovascular system morphology	Sometimes (5–29%)
Hole in heart wall separating two lower heart chambers	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Clouding of the lens of the eye	Sometimes (5–29%)
Cornea of eye less than 10mm in diameter	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Very often (80–99%)
Intellectual disability	Very often (80–99%)

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties	Very often (80–99%)

Abnormality of the ear

Trait	How often it is seen
Hearing impairment	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Recurrent respiratory infections	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TSHZ3 and how often each is seen. Find out more at hpo.jax.org.

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