Traits

Traits linked to TRAPPC10

trafficking protein particle complex subunit 10

The Human Phenotype Ontology links 26 traits to TRAPPC10, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Delayed ability to walk	Always
Delayed speech and language development	Always
Global developmental delay	Always
Intellectual disability, severe	Always
Gray matter heterotopia	Very often (80–99%)
Absent speech development	Often (30–79%)
Agenesis of corpus callosum	Often (30–79%)
Aggressive behavior	Often (30–79%)
Epilepsy	Often (30–79%)
Fewer and broader ridges in brain	Often (30–79%)
Increased reflexes	Often (30–79%)
Poor speech	Often (30–79%)
Underdeveloped frontal lobe	Often (30–79%)
Ventriculomegaly	Often (30–79%)
Waddling gait	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Very often (80–99%)
Sloping forehead	Very often (80–99%)
Thin red part of the upper lip	Very often (80–99%)
Upward slanting of the opening between the eyelids	Very often (80–99%)
Monobrow	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Absent kidney on one side	Often (30–79%)
Vesicoureteral reflux	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Always
Abnormal cortical bone morphology	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Growth delay	Very often (80–99%)
Short stature	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TRAPPC10 and how often each is seen. Find out more at hpo.jax.org.

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