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Gene

SLC11A2

solute carrier family 11 member 2

Summary

Cytogenetic location
12q13.12
Coordinates
Chromosome 12: 50,985,992–51,026,384 (GRCh38)
Exons
16 exons across 40.4 kb
Protein
561 amino acids
Inheritance
Autosomal recessive
Also known as
DCT1, DMT1, DMT-1, FLJ37416
Previous symbols
NRAMP2
MANE Select transcript
ENST00000262052.9NM_000617.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Inherited Iron Metabolism Disorders

    • Microcytic Anaemia with Liver Iron Overload (DMT1 Deficiency)Autosomal recessive

      Caused by changes in SLC11A2, which encodes the iron transporter DMT1, leading to anaemia from birth together with iron build-up in the liver.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How SLC11A2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where SLC11A2 sits. SLC11A2 and 16 genes near it on chromosome 12, from 50,506,188 to 51,506,187.Chromosome 1212q13.12p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3350.6 Mb50.8 Mb51 Mb51.2 Mb51.4 MbDIP2B: 50,504,962–50,748,657, forward strandDIP2BATF1: 50,763,710–50,821,162, forward strandATF1TMPRSS12: 50,842,920–50,887,884, forward strandTMPRSS12TMT1A: 50,923,472–50,932,510, forward strandTMT1A: 50,924,969–50,970,700, forward strandHIGD1C: 50,952,538–50,970,860, forward strandHIGD1CSLC11A2: 50,985,992–51,026,384, reverse strandSLC11A2LETMD1: 51,047,962–51,068,961, forward strandLETMD1CSRNP2: 51,061,205–51,083,664, reverse strandCSRNP2TFCP2: 51,093,656–51,173,137, reverse strandTFCP2POU6F1: 51,186,936–51,218,086, reverse strandPOU6F1DAZAP2: 51,238,724–51,272,164, forward strandDAZAP2SMAGP: 51,244,558–51,270,517, reverse strandSMAGPBIN2: 51,281,038–51,324,668, reverse strandBIN2CELA1: 51,328,442–51,346,804, reverse strandCELA1GALNT6: 51,351,247–51,392,867, reverse strandGALNT6SLC4A8: 51,391,317–51,515,763, forward strandSLC4A8Diagram of SLC11A2: 16 exons on the reverse strand of chromosome 12Exon 4: 1 known disease-causing siteExon 16: 50,985,992–50,988,435, 2,444 basesExon 15: 50,990,795–50,990,948, 154 basesExon 14: 50,991,599–50,991,672, 74 basesExon 13: 50,992,190–50,992,339, 150 basesExon 12: 50,992,810–50,992,929, 120 basesExon 11: 50,994,544–50,994,630, 87 basesExon 10: 50,995,629–50,995,787, 159 basesExon 9: 50,996,817–50,996,972, 156 basesExon 8: 50,999,174–50,999,241, 68 basesExon 7: 50,999,345–50,999,415, 71 basesExon 6: 51,000,313–51,000,419, 107 basesExon 5: 51,004,788–51,004,907, 120 basesExon 4: 51,005,311–51,005,436, 126 basesExon 3: 51,008,476–51,008,624, 149 basesExon 2: 51,010,695–51,010,766, 72 basesExon 1: 51,026,310–51,026,384, 75 bases16141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.1 kb of the gene's 40.4 kb; 1,686 of those bases code for the protein.

How a genome test reads SLC11A2

2

positions in SLC11A2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 40.4 kb of SLC11A2, introns included, not only the 4.1 kb of exons.

Traits linked to SLC11A2

The Human Phenotype Ontology lists these as features of the rare conditions SLC11A2 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SLC11A2 gene: solute carrier family 11 member 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/slc11a2

Vancouver

Dante Labs. SLC11A2 gene: solute carrier family 11 member 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/slc11a2

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