Traits

Traits linked to RHAG

Rh associated glycoprotein

The Human Phenotype Ontology links 31 traits to RHAG, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Hemolytic anemia	Always
Increased immature red blood cells	Always
Increased red cell osmotic fragility	Always
Stomatocytosis	Always
Abnormal mean corpuscular volume	Very often (80–99%)
Decreased mean corpuscular hemoglobin concentration	Very often (80–99%)
Hypochromia	Often (30–79%)
Spherocytosis	Often (30–79%)
Abnormal blood clot	Sometimes (5–29%)
Increased mean corpuscular volume	Sometimes (5–29%)
Unequal size of red blood cells	Sometimes (5–29%)
Macrocytic anemia	Rarely (1–4%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Blood clot in artery of lung	Often (30–79%)
Elevated heart rate	Sometimes (5–29%)
Enlarged liver and spleen	Sometimes (5–29%)
Increased spleen size	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Jaundice	Often (30–79%)
Intermittent yellow skin	Sometimes (5–29%)
Prolonged yellowing of skin in newborn	Sometimes (5–29%)
Enlarged liver	Not recorded

Laboratory abnormality

Trait	How often it is seen
Decreased circulating haptoglobin concentration	Very often (80–99%)
High blood bilirubin levels	Often (30–79%)
Increased circulating lactate dehydrogenase concentration	Often (30–79%)
Unconjugated hyperbilirubinemia	Not recorded

Abnormality of the respiratory system

Trait	How often it is seen
Increased respiratory rate or depth of breathing	Sometimes (5–29%)
Low blood oxygen level	Sometimes (5–29%)

Abnormal cellular phenotype

Trait	How often it is seen
Increased intracellular sodium	Not recorded

Abnormality of prenatal development or birth

Trait	How often it is seen
Low levels of amniotic fluid	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Positive direct antiglobulin test	Very often (80–99%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Prenatal growth deficiency	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to RHAG and how often each is seen. Find out more at hpo.jax.org.

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