Traits

Traits linked to NLRC4

NLR family CARD domain containing 4

The Human Phenotype Ontology links 27 traits to NLRC4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low number of red blood cells or hemoglobin	Always
Low platelet count	Always
Diffuse alveolar hemorrhage	Often (30–79%)
Disseminated intravascular coagulation	Often (30–79%)
Low blood cell count	Often (30–79%)
Reduced total natural killer cell count	Often (30–79%)
Hypofibrinogenemia	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties in infancy	Always
Secretory diarrhea	Often (30–79%)
Enterocolitis	Not recorded
Episodic vomiting	Not recorded
Villous atrophy	Not recorded

Laboratory abnormality

Trait	How often it is seen
Elevated circulating C-reactive protein concentration	Always
Elevated serum ferritin	Always
Episodic fever	Always
Fever	Always
Low albumin	Often (30–79%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Always
Joint pain	Often (30–79%)
Muscle ache	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Hives	Always
Increased spleen size	Always

Abnormality of the immune system

Trait	How often it is seen
Meningitis	Often (30–79%)
Skin rash	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Always
Short stature	Often (30–79%)

Abnormal cellular phenotype

Trait	How often it is seen
Abnormal natural killer cell physiology	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NLRC4 and how often each is seen. Find out more at hpo.jax.org.

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