Traits

Traits linked to NAA20

N-alpha-acetyltransferase 20, NatB catalytic subunit

The Human Phenotype Ontology links 35 traits to NAA20, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Always
Intellectual disability	Always
Autism	Sometimes (5–29%)
Impulsivity	Sometimes (5–29%)
Inability to coordinate movements when walking	Sometimes (5–29%)
Incoordination	Sometimes (5–29%)
Increased reflexes	Sometimes (5–29%)
Irritability	Sometimes (5–29%)
Persistent head lag	Sometimes (5–29%)
Poor speech	Sometimes (5–29%)
Recurrent hand flapping	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Downward slanting of the opening between the eyelids	Often (30–79%)
Chewing difficulties	Sometimes (5–29%)
Deep philtrum	Sometimes (5–29%)
Drooling	Sometimes (5–29%)
Eye folds	Sometimes (5–29%)
Full upper lip	Sometimes (5–29%)
Long, narrow head	Sometimes (5–29%)
Narrow forehead	Sometimes (5–29%)
Small forehead	Sometimes (5–29%)
Widely spaced teeth	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Generalized decreased muscle tone	Often (30–79%)
Low muscle tone	Sometimes (5–29%)
Osteopenia	Sometimes (5–29%)
Scoliosis	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Curvature of little finger	Often (30–79%)
Single transverse palmar crease	Often (30–79%)
Dropped arches	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Hole in heart wall separating two lower heart chambers	Often (30–79%)
Patent ductus arteriosus	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties	Sometimes (5–29%)
Poor suck	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Ears rotated toward back of head	Sometimes (5–29%)
Low-set ears	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Less than 10 fetal movements in 12 hours	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NAA20 and how often each is seen. Find out more at hpo.jax.org.

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