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Gene

MRPL3

mitochondrial ribosomal protein L3

Summary

Cytogenetic location
3q22.1
Coordinates
Chromosome 3: 131,462,212–131,502,971 (GRCh38)
Exons
10 exons across 40.8 kb
Protein
348 amino acids
Also known as
MRL3, uL3m
Previous symbols
RPML3
MANE Select transcript
ENST00000264995.8NM_007208.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Primary Mitochondrial Disease

    • Combined Oxidative Phosphorylation Deficiency

      Disorders, usually caused by nuclear genes involved in mitochondrial protein production, that reduce several respiratory chain complexes at once and often cause severe multisystem disease in childhood.

      • 2 GenCC submitters rate it definitive or strong
      Actionability

      Knowing can end a diagnostic search and guide surveillance and supportive care.

How MRPL3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 3, with a bracket where MRPL3 sits. MRPL3 and 5 genes near it on chromosome 3, from 130,982,592 to 131,982,591.Chromosome 33q22.1p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29131 Mb131.2 Mb131.4 Mb131.6 Mb131.8 MbATP2C1: 130,850,504–131,016,759, forward strandATP2C1ASTE1: 131,013,065–131,027,649, reverse strandASTE1NEK11: 131,026,845–131,353,043, forward strandNEK11NUDT16: 131,381,671–131,388,830, forward strandNUDT16MRPL3: 131,462,212–131,502,971, reverse strandMRPL3CPNE4: 131,533,555–132,285,410, reverse strandCPNE4Diagram of MRPL3: 10 exons on the reverse strand of chromosome 3Exon 10: 131,462,212–131,462,875, 664 basesExon 9: 131,468,091–131,468,168, 78 basesExon 8: 131,469,696–131,469,773, 78 basesExon 7: 131,471,171–131,471,279, 109 basesExon 6: 131,487,680–131,487,740, 61 basesExon 5: 131,489,981–131,490,080, 100 basesExon 4: 131,498,179–131,498,277, 99 basesExon 3: 131,500,430–131,500,521, 92 basesExon 2: 131,501,531–131,501,715, 185 basesExon 1: 131,502,730–131,502,971, 242 bases109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.7 kb of the gene's 40.8 kb; 1,047 of those bases code for the protein.

Sequencing MRPL3

15Moderate

How hard MRPL3 is to sequence with short reads, out of 100

Some of MRPL3's exons sit where short reads can miss or misplace a change.

What adds to it: the share of MRPL3's exons in each kind of hard region

  • Mappability5.2%
  • Homology39%
  • Repeats0.4%
  • GC content14%
  • Reference coverage0%

A Dante Labs score from our own research, built on NIST's Genome in a Bottle maps of hard-to-sequence regions.How it's scored

Genes linked to the same conditions

Traits linked to MRPL3

The Human Phenotype Ontology lists these as features of the rare conditions MRPL3 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). MRPL3 gene: mitochondrial ribosomal protein L3. Retrieved 18 October 2026, from https://dantelabs.com/genes/mrpl3

Vancouver

Dante Labs. MRPL3 gene: mitochondrial ribosomal protein L3 [Internet]. [cited 18 October 2026]. Available from: https://dantelabs.com/genes/mrpl3

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