Traits

Traits linked to MFRP

membrane frizzled-related protein

The Human Phenotype Ontology links 18 traits to MFRP, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the eye

Trait	How often it is seen
Abnormal light- and dark-adapted electroretinogram	Always
Abnormally small eyeball	Always
Decreased clarity of vision	Always
Difficulties with night vision	Always
Foveoschisis	Always
Optic disc drusen	Always
Optic disc pallor	Always
Retinal pigment epithelial atrophy	Always
Scleral thickening	Always
Severe farsightedness	Always
Spicular pigmentation of the retina	Always
Abnormal choroid morphology	Very often (80–99%)
Cross-eyed	Very often (80–99%)
Glaucoma	Very often (80–99%)
Abnormal retinal pigmentation	Sometimes (5–29%)
Angle closure glaucoma	Sometimes (5–29%)
Extreme sensitivity of the eyes to light	Sometimes (5–29%)
Retinal detachment	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MFRP and how often each is seen. Find out more at hpo.jax.org.

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