Traits

Traits linked to LGI3

leucine rich repeat LGI family member 3

The Human Phenotype Ontology links 20 traits to LGI3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Always
Intellectual disability	Always
Decreased reflex response	Often (30–79%)
Myokymia	Often (30–79%)
Anxiety	Sometimes (5–29%)
Ataxia	Sometimes (5–29%)
Attention deficit	Sometimes (5–29%)
Decreased muscle movement	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Abnormal formation of the hip	Sometimes (5–29%)
Appendicular hypotonia	Sometimes (5–29%)
Hunched back	Sometimes (5–29%)
Low muscle tone in trunk	Sometimes (5–29%)
Pigeon chest	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Involuntary facial quivering	Often (30–79%)
Narrow mouth	Often (30–79%)
Progressively abnormally small cranium	Sometimes (5–29%)
Tongue twitching	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Sometimes (5–29%)
Short stature	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Eczema	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to LGI3 and how often each is seen. Find out more at hpo.jax.org.

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