Traits

Traits linked to LDHA

lactate dehydrogenase A

The Human Phenotype Ontology links 34 traits to LDHA, by body system: features seen in people with one of the gene's rare conditions.

Laboratory abnormality

Trait	How often it is seen
Elevated creatine kinase after exercise	Often (30–79%)
Exercise-induced myoglobinuria	Often (30–79%)
Abnormal circulating lactate dehydrogenase concentration	Sometimes (5–29%)
Heat intolerance	Sometimes (5–29%)
High blood calcium levels	Sometimes (5–29%)
High liver enzymes	Sometimes (5–29%)
Elevated blood creatine phosphokinase	Not recorded
Higher than normal levels of lactate in blood	Not recorded
Increased circulating pyruvate concentration	Not recorded
Myoglobinuria	Not recorded

Abnormality of the integument

Trait	How often it is seen
Annular cutaneous lesion	Often (30–79%)
Erythematous plaque	Often (30–79%)
Psoriasiform lesion	Often (30–79%)
Regional abnormality of skin	Often (30–79%)
Scaling skin	Often (30–79%)
Intermittent generalized erythematous papular rash	Sometimes (5–29%)
Parakeratosis	Sometimes (5–29%)
Itching	Rarely (1–4%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Exercise-induced rhabdomyolysis	Often (30–79%)
Tired easily	Often (30–79%)
Breakdown of skeletal muscle	Not recorded
Muscle spasm	Not recorded
Muscle stiffness	Not recorded
Rigidity	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Acute kidney injury	Sometimes (5–29%)
Chronic kidney disease	Sometimes (5–29%)
Renal failure	Not recorded

Abnormality of the immune system

Trait	How often it is seen
Pimple	Often (30–79%)
Predominantly dermal neutrophilic infiltrate	Sometimes (5–29%)
Superficial dermal perivascular inflammatory infiltrate	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Exercise-induced muscle pain	Often (30–79%)
Decreased ability to exercise	Not recorded
Muscle ache	Not recorded

Abnormality of prenatal development or birth

Trait	How often it is seen
Abnormal delivery	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to LDHA and how often each is seen. Find out more at hpo.jax.org.

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