Traits

Traits linked to LAT

linker for activation of T cells

The Human Phenotype Ontology links 20 traits to LAT, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Increased gamma-delta T cell proportion	Always
Low T cell count	Always
Autoimmune thrombocytopenia	Often (30–79%)
Coombs-positive hemolytic anemia	Often (30–79%)
Decreased blood lymphocyte number	Often (30–79%)
Decreased total CD4+ T cell proportion	Often (30–79%)

Abnormality of the immune system

Trait	How often it is seen
Recurrent infections	Always
Recurrent pneumonia	Always
Decreased immune function	Not recorded
Immune dysregulation	Not recorded

Abnormal cellular phenotype

Trait	How often it is seen
Abnormal T cell proliferation	Always
Decreased circulating IgA concentration	Always
Decreased circulating antibody level	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Increased spleen size	Always
Swollen lymph nodes	Always

Abnormality of the respiratory system

Trait	How often it is seen
Chronic lung disease	Often (30–79%)
Permanent enlargement of the airways of the lungs	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Persistent CMV viremia	Always
Persistent EBV viremia	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to LAT and how often each is seen. Find out more at hpo.jax.org.

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