Traits

Traits linked to ITGA8

integrin subunit alpha 8

The Human Phenotype Ontology links 29 traits to ITGA8, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the genitourinary system

Trait	How often it is seen
Bilateral renal agenesis	Always
Absent kidney	Very often (80–99%)
Urogenital fistula	Often (30–79%)
Abnormal morphology of female internal genitalia	Sometimes (5–29%)
Abnormally closed or absent vagina	Not recorded
Heart shaped uterus	Not recorded
Primary amenorrhea	Not recorded
Renal dysplasia	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Potter facies	Always
Eye folds	Very often (80–99%)
Flat nose	Very often (80–99%)
Cleft palate	Sometimes (5–29%)
Non-midline cleft of the upper lip	Sometimes (5–29%)
Receding chin	Not recorded

Abnormality of prenatal development or birth

Trait	How often it is seen
Anhydramnios	Always
Low levels of amniotic fluid	Very often (80–99%)
Fetal polyuria	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Club feet	Always
Sirenomelia	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormal cardiovascular system morphology	Often (30–79%)
High blood pressure	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Abnormal connection between trachea and esophagus	Often (30–79%)
Abnormality of the intestine	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Nonketotic hypoglycemia	Very often (80–99%)
High urine protein levels	Not recorded

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Very often (80–99%)

Abnormality of the eye

Trait	How often it is seen
Wide-set eyes	Very often (80–99%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Abnormal sacrum morphology	Often (30–79%)

Abnormality of the respiratory system

Trait	How often it is seen
Poorly developed lungs	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ITGA8 and how often each is seen. Find out more at hpo.jax.org.

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