Traits

Traits linked to IFITM5

interferon induced transmembrane protein 5

The Human Phenotype Ontology links 17 traits to IFITM5, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the musculoskeletal system

Trait	How often it is seen
Osteopenia	Always
Recurrent fractures	Always
Biconcave vertebral bodies	Often (30–79%)
Hyperplastic callus formation	Often (30–79%)
Double-Jointed	Sometimes (5–29%)
Flattened vertebrae	Sometimes (5–29%)
Hyperextensibility at elbow	Sometimes (5–29%)
Wedge-shaped vertebrae	Sometimes (5–29%)
Abnormal shape of pelvic girdle bone	Not recorded

Abnormality of limbs

Trait	How often it is seen
Limited pronation/supination of forearm	Always
Anterior radial head dislocation	Often (30–79%)
Dropped arches	Sometimes (5–29%)
Finger joint hyperextensibility	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Extra bones within cranial sutures	Often (30–79%)
Triangular face	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Blue outer white part of eyeball	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Short stature	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to IFITM5 and how often each is seen. Find out more at hpo.jax.org.

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