Traits

Traits linked to GLDN

gliomedin

The Human Phenotype Ontology links 33 traits to GLDN, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Little lower jaw	Very often (80–99%)
Cleft palate	Often (30–79%)
Cystic hygroma	Often (30–79%)
Depressed nasal bridge	Often (30–79%)
Dandy-Walker malformation	Sometimes (5–29%)
Receding chin	Sometimes (5–29%)
Small retruded chin	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Arthrogryposis multiplex congenita	Very often (80–99%)
Multiple joint contractures	Very often (80–99%)
Diffuse skeletal muscle wasting	Often (30–79%)
Scoliosis	Often (30–79%)
Distal arthrogryposis	Sometimes (5–29%)
Flexed joint that cannot be straightened	Sometimes (5–29%)
Permanent flexion of the finger or toe	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Absent palm lines	Very often (80–99%)
Permanent flexion of the finger	Very often (80–99%)
Flexion contracture of finger	Often (30–79%)
Club foot on both sides	Sometimes (5–29%)
Elbow flexion contracture	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
High levels of amniotic fluid	Always
Less than 10 fetal movements in 12 hours	Always
Fetal akinesia sequence	Very often (80–99%)

Abnormality of the nervous system

Trait	How often it is seen
Akinesia	Very often (80–99%)
Decreased muscle movement	Very often (80–99%)
Excessive daytime sleepiness	Very often (80–99%)

Abnormality of the respiratory system

Trait	How often it is seen
Poorly developed lungs	Very often (80–99%)
Respiratory function loss	Very often (80–99%)

Abnormality of the digestive system

Trait	How often it is seen
Underdeveloped instestine	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Ears rotated toward back of head	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Wide-set eyes	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Undescended testes	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Pterygium	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Prenatal growth deficiency	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to GLDN and how often each is seen. Find out more at hpo.jax.org.

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