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Gene

GABRA5

gamma-aminobutyric acid type A receptor subunit alpha5

Summary

Cytogenetic location
15q12
Coordinates
Chromosome 15: 26,867,062–26,949,208 (GRCh38)
Exons
11 exons across 82.1 kb
Protein
462 amino acids
MANE Select transcript
ENST00000335625.10NM_000810.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • 2 GenCC submitters rate it definitive or strong

    How GABRA5 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 15, with a bracket where GABRA5 sits. GABRA5 and 2 genes near it on chromosome 15, from 26,408,135 to 27,408,134.Chromosome 1515q12p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.326.6 Mb26.8 Mb27 Mb27.2 Mb27.4 MbGABRB3: 26,543,552–26,939,539, reverse strandGABRB3GABRA5: 26,867,062–26,949,208, forward strandGABRA5GABRG3: 26,971,060–27,541,984, forward strandGABRG3Diagram of GABRA5: 11 exons on the forward strand of chromosome 15Exon 10: 2 known disease-causing sitesExon 1: 26,867,062–26,867,111, 50 basesExon 2: 26,868,729–26,868,793, 65 basesExon 3: 26,869,175–26,869,334, 160 basesExon 4: 26,880,846–26,880,967, 122 basesExon 5: 26,883,166–26,883,233, 68 basesExon 6: 26,883,337–26,883,557, 221 basesExon 7: 26,914,803–26,914,885, 83 basesExon 8: 26,937,185–26,937,328, 144 basesExon 9: 26,939,925–26,940,077, 153 basesExon 10: 26,943,215–26,943,426, 212 basesExon 11: 26,947,934–26,949,208, 1,275 bases1246810115′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2.6 kb of the gene's 82.1 kb; 1,389 of those bases code for the protein.

    How a genome test reads GABRA5

    2

    positions in GABRA5 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 82.1 kb of GABRA5, introns included, not only the 2.6 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). GABRA5 gene: gamma-aminobutyric acid type A receptor subunit alpha5. Retrieved 17 October 2026, from https://dantelabs.com/genes/gabra5

    Vancouver

    Dante Labs. GABRA5 gene: gamma-aminobutyric acid type A receptor subunit alpha5 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gabra5

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