Traits

Traits linked to FZD5

frizzled class receptor 5

The Human Phenotype Ontology links 15 traits to FZD5, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the eye

Trait	How often it is seen
Birth defect that causes a hole in the innermost layer at the back of the eye	Often (30–79%)
Cat eye	Often (30–79%)
Cortical cataract	Often (30–79%)
Decreased clarity of vision	Often (30–79%)
Hole in the back of the eye	Often (30–79%)
Involuntary, rapid, rhythmic eye movements	Often (30–79%)
Optic disc coloboma	Often (30–79%)
Optic disc hypoplasia	Often (30–79%)
Severe near sightedness	Often (30–79%)
Abnormally small eyeball	Sometimes (5–29%)
Cross-eyed	Sometimes (5–29%)
Extreme sensitivity of the eyes to light	Sometimes (5–29%)
Hypoplasia of the fovea	Sometimes (5–29%)
Retinal detachment	Sometimes (5–29%)
Severe farsightedness	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to FZD5 and how often each is seen. Find out more at hpo.jax.org.

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